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Gerontology Centers united to Aid Remote Research in Elders (G-CAR²E)

Award Number: R61AG094582
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Gerontology Centers united to Aid Remote Research in Elders (G-CAR²E) - Older Americans experience approximately 13 million hospitalizations and 29 million falls per year. These interfering health events (IHE - episodic falls, injuries, illnesses, and hospitalizations) are strong precipitants of disability in older adults. Because of their episodic nature, IHEs are extremely difficult to study. Continuous, long-term monitoring with remote capabilities using personal smartphones and a research-dedicated app designed by users are ideal solutions for capturing health information preceding and salutogenesis (coping & recovery) following an IHE. However, remote data capture, particularly with older adults, has been slow to gain traction. A major barrier to adoption is the technological challenges of app development and usability faced by both researchers and participants. This R61/R33 project aims to create and sustain a remote-based research infrastructure built on the foundation of a mobile software platform called Gerontology Centers to Aid Remote Research in Elders (G-CAR2E). G-CAR2E is designed for the 5M’s Geriatrics framework: Mobility, Medications, Matter’s Most, Mind and Multi-Complexity. Each M serves as a module with a pre-assembled collection of instruments, fine-tuned through stakeholder engagement with a User Advisory Board comprised of both participants and researchers. G-CAR2E will also allow researchers to customize beyond the core M's, creating and sharing instruments with the broader research community through an instrument repository. The G- CAR2E infrastructure creates 24 new collaborations while strengthening 12 additional ones from three sites (U of Florida, U. Alabama at Birmingham and Emory U.). Having multiple sites fosters cross-region collaboration, tests feasibility for scaling a national level and offsets local biases. G-CAR2E’s infrastructure contains a diverse group of investigators and a strong industry partner (App Maisters Inc.). Each will serve under concentrations of App & Software Development, Remote Data Collection and Monitoring, Data Quality and Analysis, Clinical and Cognitive Outcomes, User Center Design and Electronic Cohort (eCohort) Recruitment and Retention. An External Advisory Board and NIH/NIA will evaluate milestones at Go/No-Go checkpoints for completing the R61 development phase. In the R33 phase, we conduct a 2-year multisite prospective eCohort study (n=270) that serves as a testbed for feasibility while simultaneously validating the infrastructure with guidance from real-world experiences. It also addresses an important hypothesis— that data from G-CAR2E predicts incident major IHE defined as one of the following: hospital admission or urgent/emergent care. Additional aims evaluate salutogenesis after an IHE, which also tests the sensitivity of G-CAR2E 5M measures to standardized measures of IHE severity. Our multi-model sustainability plan prioritizes public utility over commercialization and by creating demand through our aging-centered research networks. G-CAR2E will have a low-barrier entry model with hybrid-freemium options for individuals and tiered subscriptions for institutions based on their size and research volume.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $665,690 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	1	6/30/2026	NEW	$665,690
														Subtotal = $665,690

Grand Total All Awards = $665,690

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Gerontology Centers united to Aid Remote Research in Elders (G-CAR²E)

Award Number: R61AG094582

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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