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A biobehavioral Approach to Explore the Migration-food Insecurity Nexus as a Social Determinant of Cardiovascular Health

Award Number: R56HL174589
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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A biobehavioral Approach to Explore the Migration-food Insecurity Nexus as a Social Determinant of Cardiovascular Health - PROJECT SUMMARY/ABSTRACT Food insecurity is a toxic stressor in the context of forced migration, which increases health risk and contributes to health disparities. The proposed study will capitalize on the expertise, previous work, cultural backgrounds, and community liaisons of leading scientists in migrant health, health disparities, and nutrition to conduct the first prospective, longitudinal study to use a biobehavioral approach to characterize food insecurity as a social determinant of health in a marginalized immigrant population about which little is known. In this study, our team will collect longitudinal, mixed methods data from 450 Latino immigrants varying in migration context to examine how exposure to food insecurity and trauma – concurrently and prospectively influence risk for CVD and diminished psychological well-being via the biological pathways of malnutrition and systemic inflammation. Importantly, the proposed study will also identify individual and cultural factors that might ameliorate the detrimental health effects of food insecurity on CVD risk and psychological well-being among marginalized Latino immigrants. In collaboration with established community partners, participants will be recruited from immigrant camps/shelters on both sides of the U.S.-Mexico border, along with a control/comparison group of established Latino immigrants living in the U.S. (≥ 5 years in U.S.). Using the inflammatory hypothesis of chronic stress as a conceptual framework, the proposed study incorporates state- of-the-art biological markers and mixed methods to provide novel information about biobehavioral mechanisms that underlie health risk and foster resilience across domains and levels. Specific aim 1 is to characterize the food insecurity patterns of Latino immigrants varying in history of trauma and migration context. Specific aim 2 is to characterize the concurrent and prospective relationships between food insecurity, nutritional status, inflammation, CVD risk, and psychological well-being, and to identify disparities in these associations among Latino immigrants varying in history of trauma and migration context. Specific aim 3 is to identify and understand sociocultural and personal factors that moderate the associations between nutritional status, inflammation, CVD risk, and psychological well-being among Latino immigrants varying in history of trauma and migration context. Knowledge gained from the proposed study will (1) fill a gap in the literature and propel scientific evidence about biobehavioral mechanisms through which food insecurity influences cardiovascular health and psychological well-being among Latino immigrants, while accounting for differences in the immigration experience that underlie health disparities in this immigrant population; (2) inform culture and context sensitive assessments, prevention efforts, and intervention to address food insecurity and its detrimental health effects; and (3) guide advocacy and policy to address food insecurity among a marginalized and vulnerable immigrant population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	000	1	3/24/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	000	1	7/18/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $748,647 )
2024	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	000	1	9/17/2024	NEW	$748,647
														Subtotal = $748,647

Grand Total All Awards = $748,647

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A biobehavioral Approach to Explore the Migration-food Insecurity Nexus as a Social Determinant of Cardiovascular Health

Award Number: R56HL174589

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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