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The signaling mechanism of primary cilia in aneurysm prevention

Award Number: R56HL131577
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2020

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The signaling mechanism of primary cilia in aneurysm prevention - PROJECT DESCRIPTION Aneurysm contributes significantly to mortality in patients with polycystic kidney disease (PKD). Thus, a better understanding of vascular pathology in PKD may lead to prevention and treatment for these patients. Primary cilia are known to be the mechanosensory organelles in vascular endothelia. Emerging evidence indicates that primary cilia are involved in PKD pathogenesis. Using inducible-PKD models for endothelia, the proposed study is designed to ask if and how improving cilia function could diminish aneurysm formation. Therefore, our hypothesis is to test PKD models to determine if enhancing cilia function will significantly prevent aneurysm formation. Since our previous studies indicated that activation of ciliary dopamine receptor-5 (DR5) could enhance the mechanosensory function of primary cilia, our Aim 1 will use DR5 as a candidate model to explore our hypothesis, because this is the only model system known to increase cilia function at the present time. More specifically, this aim will examine the cellular mechanisms of primary cilia function in aneurysm in vitro and in vivo. Our previous studies also indicated that genomic instability and abnormal mitotic polarity contribute to aneurysm formation. In Aim 2, we therefore ask if improving polyploidy and mitotic polarity could reduce aneurysm formation in vivo. The findings from these studies will provide useful information on the role of cilia in the regulation of vascular function and will generate new knowledge toward the understanding of vascular aneurysm.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $36 )
2022	2017	CHAPMAN UNIVERSITY	1 UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Cardiovascular Diseases Research	000	1	9/26/2022	NEW	$36
														Subtotal = $36

Issue Date FY: 2021 ( Subtotal = -$36 )
2021	2017	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Cardiovascular Diseases Research	000	1	3/9/2021	NEW	-$36
														Subtotal = -$36

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Cardiovascular Diseases Research	000	1	5/3/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $345,000 )
2017	2017	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Cardiovascular Diseases Research	000	1	9/21/2017	NEW	$345,000
														Subtotal = $345,000

Grand Total All Awards = $345,000

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The signaling mechanism of primary cilia in aneurysm prevention

Award Number: R56HL131577

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2020

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