Thursday, September 18, 2025 9/18/2025

Improved ventilation of the edematous lung

Award Number: R56HL113577
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Improved ventilation of the edematous lung - Project Summary Acute respiratory distress syndrome (ARDS) is treated by mechanical ventilation. Mechanical ventilation is a lifesaving therapy but also causes additional ventilation induced lung injury (VILI). It is not known whether VILI is attributable to overexpansion or cyclic collapse and reopening of lung tissue. In this bioengineering project, we aim to elucidate the micromechanics of the ventilation injury mechanism. We propose to test ventilation settings that keep the lung tissue expanded, allow collapse and reopening or permit collapse without reopening, and then apply a new electrical determination of alveolar-capillary barrier permeability. The new method is highly localized and independent of regional edema degree. Combining information from ventilation history and permeability characterization, we will determine cause and location of injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	ONE CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	10	9/3/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $123,642 )
2024	2023	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	ONE CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	10	5/10/2024	COMPETING CONTINUATION	$123,642
														Subtotal = $123,642

Issue Date FY: 2023 ( Subtotal = $576,525 )
2023	2023	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	1 CASTLEPOINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	10	9/25/2023	COMPETING CONTINUATION	$576,525
														Subtotal = $576,525

Grand Total All Awards = $700,167

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Improved ventilation of the edematous lung

Award Number: R56HL113577

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer