Tuesday, November 4, 2025 11/4/2025

Privacy Preservation in Transcriptomic Data Analysis

Award Number: R56HG013319
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Privacy Preservation in Transcriptomic Data Analysis - PROJECT SUMMARY Understanding the mechanism behind cellular activities requires large-scale mining of genetic and transcriptomic observations from large amounts of human data. Widespread and easy access to such data is imperative to make biological connections between genes and diseases. However, there is a direct conflict between protecting the privacy of patients and research participants and broad sharing of genetic and transcriptomic data for biomedical advances. In order to address these privacy concerns during transcriptomic analysis, we propose to take advantage of cryptographic approaches that enable direct computations on encrypted data without revealing the sensitive information in them. We will create an evolving and modular tool suite to preserve privacy; this suite will have the ability to be adopted to new data modalities and analysis needs as they arise. In particular, we propose to develop a series of tools that can quantify the bulk transcript and single-cell gene expression and perform eQTL mapping on the encrypted genotypes in a shared server and cloud setting. The proposed tools will help prevent future catastrophic privacy leaks, which may result in a loss of access to all medically actionable data. Our long-term goal is to democratize data access for all researchers and create trust between patients and researchers, thus increasing participation in studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Human Genome Research	000	1	11/6/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $855,711 )
2024	2024	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Human Genome Research	000	1	9/23/2024	NEW	$855,711
														Subtotal = $855,711

Grand Total All Awards = $855,711

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Privacy Preservation in Transcriptomic Data Analysis

Award Number: R56HG013319

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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