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In vivo microparticle sensors to study mechanics during tumor development and differentiation

Award Number: R56EB037091
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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In vivo microparticle sensors to study mechanics during tumor development and differentiation - The dynamic mechanical response of tissues is fundamental to their in vivo function. However, measuring physiologic or functional changes in tissue real time has been challenging. In this project, we propose novel stress-sensing microparticles that integrate deformable polymers and mechanomagnetic resonance (mechanoMR) nanotransducers. This magnetic microparticle provides real time monitoring of in vivo tissue mechanics with single particle resolution in a manner previously not possible. To demonstrate the utility of the novel pressure sensor, we first construct microsensor-spheroid hybrids by combining nano/microfabrication and tissue-engineering techniques. We measure the dynamic mechanical stress change during spheroid developments and structural changes (e.g. EMT transition) processes. We then apply our technology to in vivo tumor xenograft models, to dissect in vivo tumor mechanics. This project will bring broad benefits in the scientific field and the public by identifying processes to modulate methods to cellular mechanics during developmental, physiological and pathological processes. Our in vivo microsensor technology has the potential to be applied to other organ systems to monitor dynamic tissue mechanics and function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $592,108 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/19/2026	NEW	$592,108
														Subtotal = $592,108

Grand Total All Awards = $592,108

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In vivo microparticle sensors to study mechanics during tumor development and differentiation

Award Number: R56EB037091

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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