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Strategies to promote HIV-to-HIV kidney transplantation through organ donation

Award Number: R56DK149809
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Strategies to promote HIV-to-HIV kidney transplantation through organ donation - Modified Project Summary/Abstract Section Over 90% of Americans report high support for organ donation, yet only 50% are registered organ donors. This discrepancy is even more stated among some populations, such as people with HIV (PWH) of whom 80% support organ donation but only 21% are registered organ donors. This is both a medical and public health crisis as both living and deceased organ donation are critical for ensuring access to transplantation. Transplantation is the optimal treatment for people with end-stage organ disease, and end-stage kidney disease is the most prevalent of these conditions. While organ donation rates have increased year over year, they remain insufficient to meet the demand for transplantation. Moreover, there is growth in the projected number of Americans who will need a transplant due to the aging of the population and increased number of comorbid conditions. To simultaneously advance access to transplantation for PWH and reduce the demand for organs from people without HIV, the United States (US) permitted HIV-to-HIV transplant under strict regulatory guidance. In November 2024, following demonstration of excellent outcomes from HIV-to-HIV transplant, these regulatory criteria were reduced for kidney and liver transplantation. These regulatory criteria were cited by many transplant centers and organ procurement organizations as salient barriers to implementing HIV-to-HIV transplantation as standard-of-care clinical practice. As such, evaluation of clinical practice in this new regulatory environment is critical for promoting health for people both with and without HIV. To this end, this one-year R56 study is designed to 1) establish our community advisory board (CAB) and provider advisory board (PAB), 2) explore perceived barriers and facilitators to organ donation among both PWH and healthcare providers, and 3) survey healthcare providers about contemporary clinical practice and needed resources to implement HIV-to-HIV transplant as informed by the Consolidated Framework for Implementation Research. The establishment of both a community advisory board and provider advisory board will ensure study design, data collection, and data interpretation reflect both community and clinical perspectives thereby promoting identification of strategies that are both feasible and acceptable. This work furthers translational science into implementation science with an eye toward the burden placed upon both PWH and clinical providers. If successful, this work will have meaningful clinical impacts and may serve as a foundation upon which other organ systems, including liver and thoracic organs, can build. As HIV is now a chronic condition, developing effective and efficient strategies to promote the health of PWH while reducing burden has both medical and public health relevance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $639,022 )
2026	2026	UNIVERSITY OF TENNESSEE	201 ANDY HOLT TOWER	KNOXVILLE	TN	37996	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/24/2026	NEW	$639,022
														Subtotal = $639,022

Grand Total All Awards = $639,022

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Strategies to promote HIV-to-HIV kidney transplantation through organ donation

Award Number: R56DK149809

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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