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Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity

Award Number: R56DK141683
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/12/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity - If there is no change, enter No changes to the abstract or NONE. Adipocyte dyfuntion results in reduced BAT thermogenesis, low-grade chronic inflammation, fatty liver, and systemic insulin resistance. Still poorly understood are the mechanisms that trigger diet-induced obesity-associated adipocyte dysfunction. Our studies have identified that the transcription factor, interferon regulatory factor 8 (IRF8) is expressed constitutively in adipocytes of mice fed a low fat diet and when mice are fed a high fat diet (HFD) IRF8 expression is increased in white adipose tissue and brown adipose tissue adipocytes. Our preliminary studies position adipocyte IRF8 as an important transiption factor regulating brown and white adipocyte gene expression and metabolism, insulin resistance and diet-induced obesity and associated metabolic complications. Our goal is to ultimately define the specific role of IRF8 in white and brown adipocytes on adipocyte and systemic metabolism in mice fed a low fat and high fat diet to induce diet-induced obesity


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $232,000 )
2026	2026	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/12/2026	NEW	$232,000
														Subtotal = $232,000

Grand Total All Awards = $232,000

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Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity

Award Number: R56DK141683

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/12/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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