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African-American Susceptibility to Periodontal Disease due to Electronic Nicotine Delivery Systems (ENDS) Usage

Award Number: R56DE029950
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The acceptance and use of electronic nicotine delivery systems (ENDS) within the African-American (AA) community may widen tobacco-related health disparities such as gingival inflammation (GI), the precursor to periodontal disease. However, how and why ENDS use may pose GI risk is unclear as there is a lack of comprehensive data on smoking behaviors, exposure, and disease outcomes in AA ENDS users. We hypothesize that AA ENDS users may be more susceptible to ENDS-mediated oral health outcomes due to variations in ENDS preference, usage, and biological responses. To address this hypothesis, we will establish a behavior-exposure-toxicity-disease paradigm utilizing aims specifically designed to evaluate behaviors (Aim 1), common ENDS products (Aim 2), and susceptibility (Aim 3). This innovative approach will facilitate the identification of risk factors and biomarkers that can be applied to disease prevention strategies. In Aim 1, we will recruit cohorts of current AA and Caucasian ENDS users and never-tobacco users to evaluate patterns of ENDS usage behaviors, oral health, and risk factors. In this aim, we will employ questionnaires and mobile ecological momentary assessments coupled with real-time monitoring to examine ENDS puff topography within each group. By using this mixed methods approach, we will limit recall bias and also capture moment to moment phenomena that may occur differentially in these two ENDS user groups. To elucidate the role of specific group and product-based ENDS exposure scenarios we will utilize an in vitro air liquid interface cellular model system in Aim 2. Using specific group exposure scenarios (identified by puff topography characterization in Aim 1) and established protocols for comparative toxicity assessments we will identify differential biomarkers associated with ENDS aerosol exposures. Specifically, this will include comparisons of cellular responses induced by differing ENDS generation products and brands as well as usage patterns. In Aim 3, we will utilize a molecular epidemiology approach to assess the impact of differential exposures in our AA and Caucasian ENDS cohorts by using participant saliva and gingival cells to identify biomarkers of oxidative stress, DNA damage, and other indicators commonly found in GI. Specifically, we aim to establish a pathway between ENDS preference, puff topography, and toxicological pathways contributing GI development that may be exacerbated in the AA population. Our project outcomes will be a biomarker panel that may provide critical insight into ENDS-mediated GI susceptibility in AA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$9,764 )
2024	2021	UNDERWRITERS LABORATORIES INC	333 PFINGSTEN RD	NORTHBROOK	IL	60062	COOK	USA	Oral Diseases and Disorders Research	000	2	4/8/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$9,764
														Subtotal = -$9,764

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Oral Diseases and Disorders Research	000	1	11/10/2022	NEW	$0
2023	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Oral Diseases and Disorders Research	001	1	8/31/2023	NEW	$3,310
2023	2021	UNDERWRITERS LABORATORIES INC	333 PFINGSTEN RD	NORTHBROOK	IL	60062	COOK	USA	Oral Diseases and Disorders Research	002	2	8/31/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$3,310
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Oral Diseases and Disorders Research	000	1	3/10/2022	NEW	-$273,656
2022	2021	UNDERWRITERS LABORATORIES INC.	333 PFINGSTEN RD	NORTHBROOK	IL	60062	COOK	USA	Oral Diseases and Disorders Research	003	2	4/14/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$273,657
2022	2021	UNDERWRITERS LABORATORIES INC.	333 PFINGSTEN RD	NORTHBROOK	IL	60062	COOK	USA	Oral Diseases and Disorders Research	001	2	3/11/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$273,657
2022	2021	UNDERWRITERS LABORATORIES INC.	333 PFINGSTEN RD	NORTHBROOK	IL	60062	COOK	USA	Oral Diseases and Disorders Research	002	2	4/12/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$273,657
														Subtotal = $1

Issue Date FY: 2021 ( Subtotal = $353,811 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Oral Diseases and Disorders Research	001	1	9/22/2021	NEW	$0
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Oral Diseases and Disorders Research	000	1	9/3/2021	NEW	$353,811
														Subtotal = $353,811

Grand Total All Awards = $344,048

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African-American Susceptibility to Periodontal Disease due to Electronic Nicotine Delivery Systems (ENDS) Usage

Award Number: R56DE029950

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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