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Bench to the Community: Multi-Omics Approach to Discovery and Community-led Implementation Science

Award Number: R56DE028300
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Bench to the Community: Multi-Omics Approach to Discovery and Community-led Implementation Science - Project Summary/Abstract Orofacial clefts (OFCs) are the most common birth defects in the head and neck region. In families with OFCs, there are significant financial, educational, medical, psychological, and cultural problems with reports of infanticides due to pressures of stigmatization and a lack of sociocultural support for affected families. This proposal focuses on the discovery and prioritization of risk variants for clefts (Aim1), functional and mechanistic studies for the human variants (Aim 2) and implementation science involving community gatekeepers and mental health of caregivers (Aim 3). The completion of these Aims will identify and validate risk loci using multi- omics approaches, provide mechanistic understanding of how these variants and genes cause clefts and allow us to extend our community gatekeepers and mental health of caregivers studies to diverse African populations in Africa.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,260,295 )
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Oral Diseases and Disorders Research	000	6	6/23/2026	COMPETING CONTINUATION	$1,260,295
														Subtotal = $1,260,295

Grand Total All Awards = $1,260,295

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Bench to the Community: Multi-Omics Approach to Discovery and Community-led Implementation Science

Award Number: R56DE028300

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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