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Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury

Award Number: R56AR084847
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/22/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury - PROJECT SUMMARY Chemical vesicants such as sulfur mustard (SM) and nitrogen mustard (NM) act as alkylating agents causing severe skin injuries characterized by blistering, necrosis, and persistent pathology. Both pose significant threats to civilians and warfighters, yet no approved therapeutics exist for managing vesicant-induced skin injuries. This project addresses this critical medical gap by developing innovative multifunctional wound dressings engineered to simultaneously target cell membrane damage, chronic inflammation, and secondary infection—the primary pathological mechanisms underlying vesicant-induced skin trauma. Our therapeutic approach centers on MG53, a TRIM family protein with demonstrated efficacy in cell membrane repair and wound healing. Beyond its membrane-protective functions, MG53 enhances regenerative capacity in diabetic wounds by revitalizing hair follicle stem cell activity and exerts potent anti-inflammatory effects through NF-κB pathway modulation. Building on these mechanistic insights, we will develop transformative wound dressings that integrate a novel rapid-gelling antimicrobial hydrogel with recombinant human MG53 (rhMG53) protein. We hypothesize that this synergistic combination will dramatically accelerate wound healing and tissue regeneration following chemical vesicant exposure. The goal of this project is to engineer and optimize multifunctional wound dressings combining rapid-gelation antimicrobial hydrogel technology with rhMG53 protein for vesicant-induced cutaneous injuries. Successful completion will yield breakthrough multifunctional wound dressings with integrated tissue repair, anti-inflammatory, and antimicrobial capabilities. These shelf-stable therapeutic platforms can be strategically stockpiled and rapidly deployed as essential medical countermeasures against chemical vesicant exposure, addressing both immediate clinical needs and national security preparedness requirements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $387,449 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	6/23/2026	NEW	$387,449
														Subtotal = $387,449

Grand Total All Awards = $387,449

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Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury

Award Number: R56AR084847

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/22/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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