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Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 Diabetes

Award Number: R56AG080816
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 Diabetes - Abstract More than 34 million individuals in the U.S. are living with Type 2 Diabetes (DM). Adult females who belong to underrepresented racial and ethnic groups are most negatively impacted by risks and complications associated with DM, including functional impairment in cognitive and sensorimotor actions. Prior work in understanding the cortical complications in persons with DM (including the development of vascular dementia (VD)) has focused on independent risk factors such as insufficient sleep and inflammation. DM complications have also been linked to obstructive sleep apnea (OSA) and sex-hormone changes during the transition to menopause; however, most studies have included only white non-Hispanic persons. Due to this, we have limited insight into the multifactorial causes of poor cortical health including DM, sex-hormone influences, inflammation, and OSA in the most dramatically impacted population living with DM—underrepresented women. In this project, we seek to fill this critical gap by clarifying how sex-hormones (estrogen and testosterone), inflammation, and OSA contribute together to the pathogenesis of cortical complications in underrepresented women living with DM. This proposed project is a logical extension of our recent work that provides mechanistic insight into the compound contributions of menopause and inflammation to cortical complications and functional impairment in underrepresented women with DM. Findings from this study will advance understanding of poor cortical health as a combined function of sex-hormone changes, inflammation, and OSA in underrepresented middle-aged women with DM. This information pushes forward beyond the knowledge of DM, insufficient sleep, inflammation, and underrepresented minority status as independent risk factors for VD development. This project aligns with NHLBI objectives of prevention of heart, lung, blood, and sleep diseases and priorities in in women’s health, sleep disorders, health disparities, and VD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Aging Research	000	2	12/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Aging Research	000	2	8/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $669,550 )
2024	2024	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Aging Research	000	2	7/12/2024	NON-COMPETING CONTINUATION	$669,550
														Subtotal = $669,550

Issue Date FY: 2023 ( Subtotal = $689,035 )
2023	2023	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Aging Research	000	1	9/19/2023	NEW	$689,035
														Subtotal = $689,035

Grand Total All Awards = $1,358,585

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Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 Diabetes

Award Number: R56AG080816

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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