Wednesday, October 1, 2025 10/1/2025

Leveraging Nanoparticle Interactions with Host Immune Cells to Detect and Treat Cancer

Award Number: R50CA305053
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/04/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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Leveraging Nanoparticle Interactions with Host Immune Cells to Detect and Treat Cancer - Abstract The goal of this proposal is to support Dr. Preethi Korangath, as a Laboratory Research Specialist at Dr. Robert Ivkov’s laboratory in Johns Hopkins University. With her expertise in mouse models, molecular biology and imaging she will facilitate successful completion of R0-1 projects in unit director’s lab. Dr. Korangath’s successful career is evident through her publications in high impact journals and conference presentations. This Research Specialist Award will provide protected salary support for Dr. Korangath to pursue new directions and developing new technologies that enable early detection and treatment of cancer. Despite advances in cancer treatment and understanding, metastasis remains the main challenge in extending cancer patients' lives. Early detection of metastatic disease is crucial for effective treatment. Developing new imaging modalities to detect micrometastases using magnetic particle imaging (MPI) offers a non-invasive, radiation-free approach with high sensitivity and specificity. This could revolutionize cancer diagnostics and treatment, improving patient outcomes. However, further understanding of MPI's clinical applications is necessary. Dr. Korangath equipped with expertise in various mouse models and imaging techniques aims to leverage MPI for early metastasis detection and study the role of host cells in cancer progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $144,193 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Detection and Diagnosis Research	000	1	9/4/2025	NEW	$144,193
														Subtotal = $144,193

Grand Total All Awards = $144,193

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Leveraging Nanoparticle Interactions with Host Immune Cells to Detect and Treat Cancer

Award Number: R50CA305053

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/04/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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