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Overcoming Challenges Posed by Biomarker-Selective Clinical Trials: The Role of a Research Specialist

Award Number: R50CA275932
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Overcoming Challenges Posed by Biomarker-Selective Clinical Trials: The Role of a Research Specialist - Project Summary/Abstract Molecular testing and targeted therapies have revolutionized cancer care resulting in better outcomes for patients. The number of biomarker-selective clinical trials continues to increase presenting challenges for cancer centers to adapt processes for efficient identification and enrollment of patients to these clinical trials. Furthermore, there is a gap in uptake of molecular testing and clinical trial enrollment for minority and underserved populations. Addressing these challenges plays an important role in ensuring equitable and effective care for all patients. The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center is an NCI- designated Comprehensive Cancer Center and one of eight with lead roles in both the NCI Experimental Therapeutics Clinical Trials Network (ETCTN) and NCI National Clinical Trials Network (NCTN). Biomarker- selective studies are a major focus of these two networks. In this R50 Project, Dr. Gaillard will focus on addressing challenges in patient enrollment to biomarker-selective trials. The work will focus on three approaches: (i) development of a molecular registry to improve process of patient identification and determination of patient eligibility at the Center level, (ii) facilitate timely referrals to biomarker-selective trials using an electronic medical record clinical trials alert for eligible patients at the Physician level, and (iii) provide study-eligible patients with timely education on the role of biomarkers in treatment decision making (Patient level). The long term goal of this program is to develop a streamlined conduit for identifying, referring and enrolling patients for personalized medicine trials. Successful development will enhance accrual to NCI- sponsored clinical trials and be translatable to other cancer centers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $105,619 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Cause and Prevention Research	000	3	2/13/2025	NON-COMPETING CONTINUATION	$105,619
														Subtotal = $105,619

Issue Date FY: 2024 ( Subtotal = $105,619 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Cause and Prevention Research	001	2	2/27/2024	NON-COMPETING CONTINUATION	$105,619
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Cause and Prevention Research	000	1	1/2/2024	NEW	$0
														Subtotal = $105,619

Issue Date FY: 2023 ( Subtotal = $121,863 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Cause and Prevention Research	000	1	1/26/2023	NEW	$121,863
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Cause and Prevention Research	001	1	5/24/2023	NEW	$0
														Subtotal = $121,863

Grand Total All Awards = $333,101

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Overcoming Challenges Posed by Biomarker-Selective Clinical Trials: The Role of a Research Specialist

Award Number: R50CA275932

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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