Thursday, March 12, 2026 3/12/2026

High dimensional digital pathology to investigate the tumor micro environment and its impact on response to therapy

Award Number: R50CA252138
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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High dimensional digital pathology to investigate the tumor micro environment and its impact on response to therapy - Summary Grant: Research Specialist (PAR-19-291) Under the supervision of senior scientist Zoltan Maliga PhD, investigators and staff at the Harvard Medical School Laboratory of Systems Pharmacology (LSP) will contribute to cell and tissue imaging and analysis for U2C and U54 program grants LSP-based investigators will perform the tissue-based cyclic immunofluorescence (t-CyCIF) method developed at HMS on FFPE human and mouse skin samples provided by investigators and will work together to define and validate antibodies to stain biomarkers of skin development, inflammation, melanoma progression and tumor microenvironment and will share technologies under development to further advance the t-CyCIF method (e.g. switch to six-channel imaging, use of oligo-modified antibodies as detection reagents, combination of in situ hybridization or sequencing methods). The LSP will process t-CyCIF images, provide quantitative cell and tissue-level analysis and help distribute high-resolution multiplexed images as part of a disease pathology atlas. Maliga will work with PIs Lian, Murphy, LeBoeuf, Haigis, Aster to prepare manuscripts, write reports for the NIH and collaborate with other members of the project teams as required the by PAR-19-291.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$501 )
2026	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	5	12/18/2025	NON-COMPETING CONTINUATION	-$501
														Subtotal = -$501

Issue Date FY: 2024 ( Subtotal = $201,041 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	5	8/12/2024	NON-COMPETING CONTINUATION	$201,041
														Subtotal = $201,041

Issue Date FY: 2023 ( Subtotal = $201,041 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	4	8/21/2023	NON-COMPETING CONTINUATION	$201,041
														Subtotal = $201,041

Issue Date FY: 2022 ( Subtotal = $215,543 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	3	9/1/2022	NON-COMPETING CONTINUATION	$215,543
														Subtotal = $215,543

Issue Date FY: 2021 ( Subtotal = $215,543 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	2	8/23/2021	NON-COMPETING CONTINUATION	$215,543
														Subtotal = $215,543

Issue Date FY: 2020 ( Subtotal = $215,543 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	1	8/24/2020	NEW	$215,543
														Subtotal = $215,543

Grand Total All Awards = $1,048,210

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High dimensional digital pathology to investigate the tumor micro environment and its impact on response to therapy

Award Number: R50CA252138

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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