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A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer

Award Number: R50CA211499
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer - Project Summary / Abstract The Paulovich laboratory is a translational oncology lab specializing in proteomics with a goal to improve personalized medicine through elucidating cancer mechanisms, diagnosing disease, and predicting response to therapy. A major roadblock to achieving these goals is the lack of standardized assays for the quantification of proteins, which form the basis of diagnostics and are targets for treatments. To address this need, our research program is focusing on three arms: i) the development of novel applications of targeted mass spectrometry for precise, multiplexed, and reproducible quantitation of proteins, ii) the standardization of protein measurements through establishing community resources for the dissemination of the technology to the biomedical research community, and iii) the measurement of proteins and post-translational modifications in biological samples for fundamental biological insight to cancer mechanisms and translating findings to clinical use. Dr. Jeffrey Whiteaker, a research specialist in the Paulovich laboratory, is vital to achieving success in this interdisciplinary effort due to: his role as leader of all proteomics activities in the laboratory, his vast experience in the field of analytical chemistry and mass spectrometry, and the guidance he provides within the laboratory. He will continue to guide efforts aimed at expanding the technology to cancer-relevant pathways and disseminating the technology to the biomedical research community, enabling the translation of new discoveries to clinical care and the benefit of patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $310,761 )
2026	2026	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	10	8/18/2026	NON-COMPETING CONTINUATION	$310,761
														Subtotal = $310,761

Issue Date FY: 2025 ( Subtotal = $310,761 )
2025	2025	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	9	8/18/2025	NON-COMPETING CONTINUATION	$310,761
														Subtotal = $310,761

Issue Date FY: 2024 ( Subtotal = $310,761 )
2024	2024	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	8	8/13/2024	NON-COMPETING CONTINUATION	$310,761
														Subtotal = $310,761

Issue Date FY: 2023 ( Subtotal = $310,761 )
2023	2023	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	001	7	9/13/2023	NON-COMPETING CONTINUATION	$28,082
2023	2023	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	7	8/30/2023	NON-COMPETING CONTINUATION	$282,679
														Subtotal = $310,761

Issue Date FY: 2022 ( Subtotal = $306,831 )
2022	2022	FRED HUTCHINSON CANCER CENTER	1100 FAIRVIEW AVE N	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	001	6	9/14/2022	COMPETING CONTINUATION	$310,761
2022	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	5	12/23/2021	NON-COMPETING CONTINUATION	-$3,930
														Subtotal = $306,831

Issue Date FY: 2020 ( Subtotal = $257,484 )
2020	2020	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	5	7/21/2020	NON-COMPETING CONTINUATION	$257,484
														Subtotal = $257,484

Issue Date FY: 2019 ( Subtotal = $257,484 )
2019	2019	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	4	7/24/2019	NON-COMPETING CONTINUATION	$257,484
														Subtotal = $257,484

Issue Date FY: 2018 ( Subtotal = $257,484 )
2018	2018	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	3	8/7/2018	NON-COMPETING CONTINUATION	$257,484
														Subtotal = $257,484

Issue Date FY: 2017 ( Subtotal = $257,484 )
2017	2017	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE N J6-300	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	2	8/14/2017	NON-COMPETING CONTINUATION	$257,484
														Subtotal = $257,484

Issue Date FY: 2016 ( Subtotal = $257,484 )
2016	2016	FRED HUTCHINSON CANCER RESEARCH CENTER	1100 FAIRVIEW AVE NO J6-330	SEATTLE	WA	98109	KING	USA	Cancer Detection and Diagnosis Research	000	1	9/19/2016	NEW	$257,484
														Subtotal = $257,484

Grand Total All Awards = $2,837,295

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A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer

Award Number: R50CA211499

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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