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Bone marrow-targeted extracellular vesicles as a novel non-viral gene editor delivery platform

Award Number: R44TR004238
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Bone marrow-targeted extracellular vesicles as a novel non-viral gene editor delivery platform - Despite advances in gene therapy techniques, novel methods that facilitate tight targeting of gene therapy products to specific tissues and cell types are necessary to achieve widespread clinical applicability. Inherited hematologic diseases represent an ideal target for novel genetic therapies, as gene therapy approaches can bypass the significant limitations associated with bone marrow transplantation and symptomatic treatment. Extracellular vesicles (EVs) capable of targeting hematopoietic stem cells (HSCs) are a promising option for the targeted delivery of gene editor machinery to treat genetic hematologic diseases. Successful system development represents a billion-dollar market opportunity that will be defined by the ability to show: (1) targeting specificity, (2) a favorable safety profile, and (3) efficient in vivo delivery of gene editor machinery. We have developed a proprietary EV-based system for in vivo nucleic acid and protein delivery that specifically targets HSCs in bone marrow, is amenable to large scale/commercial manufacture, and presents with low immunogenicity which confers unique potential for repeat dosing. Our hypothesis is that the STRM.BIO EV-based system can be efficiently loaded with gene editor cargo, safely home to the bone marrow following intravenous delivery, and effectively edit targeted genes in HSCs. With funds provided by this Phase II award, we will (1) establish SOPs for loading STRM.BIO EVs with cargo, (2) characterize the biodistribution and delivery pattern of cargo-loaded EVs, and (3) verify feasibility of STRM.BIO EVs for in vivo cargo delivery in a mouse model of human genetic hematologic disease. The current proposal aims to establish pre-clinical proof-of-concept support for the use of our proprietary system as a non-viral, in vivo genome editor delivery system for the treatment of inherited hematologic diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$210,934 )
2026	2023	STRM.BIO INCORPORATED	750 MAIN ST	CAMBRIDGE	MA	02139	MIDDLESEX	USA	National Center for Advancing Translational Sciences	000	2	11/17/2025	NON-COMPETING CONTINUATION	-$210,934
														Subtotal = -$210,934

Issue Date FY: 2023 ( Subtotal = $1,047,299 )
2023	2023	STRM.BIO INCORPORATED	127 WESTERN AVE	ALLSTON	MA	02134	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	6/1/2023	NON-COMPETING CONTINUATION	$1,047,299
														Subtotal = $1,047,299

Issue Date FY: 2022 ( Subtotal = $1,004,289 )
2022	2022	STRM.BIO INCORPORATED	127 WESTERN AVE	ALLSTON	MA	02134	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	1	6/30/2022	NEW	$1,004,289
														Subtotal = $1,004,289

Grand Total All Awards = $1,840,654

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Bone marrow-targeted extracellular vesicles as a novel non-viral gene editor delivery platform

Award Number: R44TR004238

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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