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Multiplexed high-content assay for toxicity profiling using live iPSC-derived cardiomyocyte lines with lineage-specific barcoding

Award Number: R44TR002572
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 10/31/2020

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Multiplexed high-content assay for toxicity profiling using live iPSC-derived cardiomyocyte lines with lineage-specific barcoding - Project Summary/Abstract Human induced pluripotent stem cells (hiPSCs) are poised to transform toxicological evaluation, however new approaches to enable their functional and structural profiling are needed to improve the utility of hiPSC -based models for predictive and mechanistic toxicology screening. This need is addressed by our project’s Specific Aims that encompass (1) development of a novel platform for generation of hiPSC-derived reporter cells; (2) generation of a panel of multicolor hiPSC-derived cardiomyocytes (hiPSC-CMs) with stable lineage specific fluorescent reporters; and (3) implementation and validation of a pilot machine learning-enabled predictive cardiotoxicity screen using these tools. The proposed tools are configured to be extensible to other toxicology- relevant pathways and phenotypes making it uniquely positioned to capitalize on the growing commercial need for high-throughput predictive toxicology assays. The project deliverables benefit public health by improving the ability to rapidly identify liabilities in specific cardiomyocyte lineage types, thus reducing the time and cost to pinpoint cardiotoxicity of pharmaceutical and environmental chemicals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$3 )
2021	2019	CAIRN BIOSCIENCES, INC.	455 MISSION BAY BLVD SOUTH, SUITE 145	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	National Center for Advancing Translational Sciences	000	3	5/29/2021	NON-COMPETING CONTINUATION	-$3
														Subtotal = -$3

Issue Date FY: 2019 ( Subtotal = $821,559 )
2019	2019	CAIRN BIOSCIENCES, INC.	455 MISSION BAY BLVD SOUTH, SUITE 145	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	National Center for Advancing Translational Sciences	001	3	8/7/2019	NON-COMPETING CONTINUATION	$821,559
2019	2018	CAIRN BIOSCIENCES, INC.	455 MISSION BAY BLVD SOUTH, SUITE 145	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	National Center for Advancing Translational Sciences	000	2	8/1/2019	COMPETING CONTINUATION	$0
														Subtotal = $821,559

Issue Date FY: 2018 ( Subtotal = $1,178,386 )
2018	2018	CAIRN BIOSCIENCES, INC.	455 MISSION BAY BLVD SOUTH, SUITE 145	SAN FRANCISCO	CA	94158	SAN FRANCISCO	USA	National Center for Advancing Translational Sciences	000	2	8/9/2018	COMPETING CONTINUATION	$1,178,386
														Subtotal = $1,178,386

Grand Total All Awards = $1,999,942

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Multiplexed high-content assay for toxicity profiling using live iPSC-derived cardiomyocyte lines with lineage-specific barcoding

Award Number: R44TR002572

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 10/31/2020

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