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Next generation spatial genomics tools for the human brain

Award Number: R44MH140731
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Next generation spatial genomics tools for the human brain - SUMMARY Spatial genomics in human brain tissues has the ability to visualize gene expression programs in complex cell interactions that are involved in many neurological disorders. However, current spatial technology is often limited by the high autofluorescence in human brain samples and the poor RNA quality. At Spatial Genomics, we have commercialized the Gene Positioning System (GenePS) platform that is based on the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows 10,000 genes to be imaged directly in tissue samples. The major goal of this project is to develop next generation reagents to scale up the multiplexity of assays available on the GenePS instrument. We will develop new assays that can be performed robustly across human brain tissues by the GenePS platform.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,244,076 )
2025	2025	SPATIAL GENOMICS, INC.	145 VISTA AVE STE 111	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	1	5/30/2025	NEW	$1,244,076
														Subtotal = $1,244,076

Grand Total All Awards = $1,244,076

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Next generation spatial genomics tools for the human brain

Award Number: R44MH140731

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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