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Multi-modal spatial genomics in the mouse and human brains

Award Number: R44MH133530
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2023
PERIOD OF PERFORMANCE END DATE: 09/30/2025

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Multi-modal spatial genomics in the mouse and human brains - SUMMARY The major goal of this project is to build upon our existing expertise and platform to develop spatial multi-omics tools in human brains. At Spatial Genomics, we are commercializing the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to be imaged directly in brain samples. We have developed extensive experience working with mouse and human brains with our seqFISH technology. Spatial genomics methods have the potential to identify novel cell types, reveal spatial organization of groups of cells and subcellular patterns, and elucidate signaling interactions between neighboring cells in the brain. Identifying the spatial organization of the human brain at cellular resolution from single cell gene expression profiles is essential to understanding neuronal circuits and interactions between neurons and glia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	SPATIAL GENOMICS, INC.	145 VISTA AVE STE 111	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	2	1/6/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	SPATIAL GENOMICS, INC.	145 VISTA AVE STE 111	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	2	6/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,337,968 )
2024	2024	SPATIAL GENOMICS, INC.	145 VISTA AVE STE 111	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	2	5/6/2024	NON-COMPETING CONTINUATION	$1,337,968
														Subtotal = $1,337,968

Issue Date FY: 2023 ( Subtotal = $1,337,968 )
2023	2023	SPATIAL GENOMICS, INC.	145 VISTA AVE STE 111	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	1	6/14/2023	NEW	$1,337,968
														Subtotal = $1,337,968

Grand Total All Awards = $2,675,936

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Multi-modal spatial genomics in the mouse and human brains

Award Number: R44MH133530

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2023

PERIOD OF PERFORMANCE END DATE: 09/30/2025

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