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High Density, Miniaturized, Zero Switching, Stimulation and Recording Headstage for Small Animals

Award Number: R44MH114776
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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High Density, Miniaturized, Zero Switching, Stimulation and Recording Headstage for Small Animals - Project Summary/Abstract Combining high channel count electrophysiological recording of neural activity with patterned electrical micro- stimulation has been severely constrained by technical limitations. Foremost among these limitations are the problems associated with simultaneous recording and micro-stimulation. Stimulation artifacts are up to four orders of magnitude larger than the neural signal being sensed. The large signal drives the amplifiers outside of their linear range and traditional AC coupled amplifiers require long settling times to recover. These long settling times are due to long time constants created by low frequency high pass filters. One traditional approach to avoid amplifier saturation is to employ switches for electrode, headstage amplifier, and stimulator connections to rapidly switch between recording and stimulation. Switches must be employed to disconnect the stimulator when recording to avoid amplifier saturation and degrading the high impedance electrode signal from parasitic cable capacitances and interference sources. This project will develop a research tool for neuroscientists that will achieve electrical stimulation and neural signal recording from the same microelectrode. Multiple channels of simultaneous recording and micro-stimulation from the same electrode are combined on the same integrated circuit (IC) for integration in a headstage. The integration in an IC eliminates signal degradation and interference from cabling and switching parasitic effects. Additionally, the low-noise amplifier circuitry, stimulation circuitry and local control may be intimately tied to mitigate the electrode polarization recovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	ADVANCED MEDICAL ELECTRONICS CORP	6901 E FISH LAKE RD	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	000	3	9/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	000	3	3/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $696,906 )
2019	2019	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	002	3	9/19/2019	NON-COMPETING CONTINUATION	$0
2019	2019	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	001	3	3/5/2019	NON-COMPETING CONTINUATION	$696,906
2019	2018	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	000	2	3/2/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $696,906

Issue Date FY: 2018 ( Subtotal = $768,391 )
2018	2018	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	001	2	3/19/2018	EXTENSION WITH OR WITHOUT FUNDS	$23,486
2018	2018	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	000	2	3/2/2018	EXTENSION WITH OR WITHOUT FUNDS	$744,905
2018	2017	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	002	1	5/8/2018	NEW	$0
														Subtotal = $768,391

Issue Date FY: 2017 ( Subtotal = $224,957 )
2017	2017	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Mental Health Research Grants	000	1	7/28/2017	NEW	$224,957
														Subtotal = $224,957

Grand Total All Awards = $1,690,254

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High Density, Miniaturized, Zero Switching, Stimulation and Recording Headstage for Small Animals

Award Number: R44MH114776

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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