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Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI

Award Number: R44MH112210
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2021

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Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI - DESCRIPTION (provided by applicant): MRI phase contrast velocity imaging is a widely disseminated on nearly all MRI scanners used for clinical diagnosis of brain disease, cardiac and cardiovascular disease and for neuroscience research. Currently phase contrast imaging of blood flow and CSF motion requires longer scan times with each 2D slice or 3D spatial image requiring additional dimension of velocity encoding requiring greater acquisition time. Given the physiological variation in heart rate, cardiac stroke output and respiratory motion effects on blood and CSF velocity, no less the need to greatly reduce the patients time in the scanner, there is a need to reduce the scan time of phase contrast imaging. To achieve several times faster imaging we propose to develop novel technology to acquire velocity phase images simultaneously instead of seperately. Our new technique called simultaneous multi-slice imaging (SMS) phase contrast (PC) imaging is innovated to obtain 2 -10 phase contrast images recorded simultaneously resulting in nearly this factor of reciprocal reduction in scan time. The availability of the new simultaneous phase contrast imaging technology will give clinicians and researchers the capability of performing significantly improved MRI perfusion measurements in the and these improvements will impact the diagnosis of many different diseases, including stroke, cardiac, cardiovascular diseases. Additionally blood flow and CSF flows which are important quantitative biomarkers useful as physiological imaging in evaluating new drug therapies for diseases. This family of new phase contrast imaging techniques utilizes more efficient pulse sequences that provide major advantages in resolution, slice coverage, SNR and speed. The new simultaneous imaging will have high utility and be highly desirable for use on clinical scanners worldwide. The improved quantitative MRI blood flow imaging offers overall increased speed that is highly commercializable given they provide improved diagnostic approaches to evaluate diseases and further improve specificity and sensitivity in MRI exams. The new technology will be designed, implemented and evaluated on MRI scanners at University of California Berkeley, University of California San Francisco (UCSF) Medical Center, Harvard Medical School, and Cedar-Sinai Medical Center. Once imaging protocols are optimized they will be further evaluated and optimized in collaborative clinical test sites in Europe, including the major cardiovascular hospital in London, the Royal Brompton Hospital and elsewhere. In addition to establishing their value in medical exams, the simultaneous phase contrast imaging will be made into useful tools for basic and clinical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2017	ADVANCED MRI TECHNOLOGIES LLC	652 PETALUMA WAY STE I	SEBASTOPOL	CA	95472	SONOMA	USA	Mental Health Research Grants	000	2	10/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	ADVANCED MRI TECHNOLOGIES LLC	652 PETALUMA WAY STE I	SEBASTOPOL	CA	95472	SONOMA	USA	Mental Health Research Grants	000	2	7/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	ADVANCED MRI TECHNOLOGIES LLC	652 PETALUMA WAY STE I	SEBASTOPOL	CA	95472	SONOMA	USA	Mental Health Research Grants	000	2	8/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $1,369,104 )
2017	2017	ADVANCED MRI TECHNOLOGIES LLC	652 PETALUMA WAY STE I	SEBASTOPOL	CA	95472	SONOMA	USA	Mental Health Research Grants	000	2	7/26/2017	NON-COMPETING CONTINUATION	$1,369,104
														Subtotal = $1,369,104

Issue Date FY: 2016 ( Subtotal = $1,287,772 )
2016	2016	ADVANCED MRI TECHNOLOGY, INC	652 PETALUMA, SUITE J	SEBASTOPOL	CA	95472	SONOMA	USA	Mental Health Research Grants	000	1	7/28/2016	NEW	$1,287,772
														Subtotal = $1,287,772

Grand Total All Awards = $2,656,876

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Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI

Award Number: R44MH112210

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2021

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