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Computerized Social Cognition training for Schizophrenia

Award Number: R44MH091793
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/05/2011
PERIOD OF PERFORMANCE END DATE: 05/02/2016

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Computerized Social Cognition training for Schizophrenia - DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized, web-deliverable, social cognition training program (SocialVille) for schizophrenia completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. Individuals with schizophrenia have severely degraded functional abilities and extremely poor life outcomes. These poor outcomes are strongly associated with pervasive deficits in social cognition: the difficulty in perception, interpretatio and processing of social information. Social cognition deficits not only underlie social functionin in schizophrenia, but also importantly affect occupational status, relapse rate, and overall qualit of life. This makes social cognition recovery a key goal for therapeutic interventions in schizophrenia. Despite the great need, there is currently no well-accepted or even broadly-administered method for improving social cognitive function in this large patient group. SocialVille was constructed to meet this need. In the Phase I project, we have developed SocialVille as a web-deliverable tool targeting the core domains of social cognition deficits in schizophrenia. SocialVille was designed to be clinician-prescribed and monitored, using a dedicated, state-of-the-art clinician portal. Our Phase I studies provided strong evidence for the feasibility of SocialVille in schizophrenia, as well as promising initial efficacy data showing significant improvements in social cognition, social function, motivation and source memory following SocialVille training, accompanied by neural-level changes in social brain areas. The successful completion of the Phase II project should provide rigorous efficacy data of the effects of SocialVille on social cognition and functional capacity (co-primary outcomes), and on functional outcome, quality of life and motivation (secondary outcomes). This outcomes data should be sufficient for submission to the FDA for clearance as a medical device indicated for the treatment of social cognition and related real-world functional abilities in schizophrenia. The resulting product, to be commercialized as the first online, clinician- monitored therapy for socia cognitive deficits, will therefore provide a cost-effective and highly-scalable treatment option fo this largely unmet clinical need, easily integrated into current health-care ecosystem in schizophrenia. As such, it is expected to help relieve the societal, functional, and economic burden associated with this devastating illness.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2016	POSIT SCIENCE CORPORATION	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Mental Health Research Grants	000	6	9/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2016	BRAIN PLASTICITY INC.	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Mental Health Research Grants	001	5	9/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	POSIT SCIENCE CORPORATION	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Mental Health Research Grants	000	6	9/10/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $11,702 )
2017	2014	BRAIN PLASTICITY INC.	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Mental Health Research Grants	000	3	5/9/2017	COMPETING CONTINUATION	$11,702
														Subtotal = $11,702

Issue Date FY: 2016 ( Subtotal = $366,656 )
2016	2016	POSIT SCIENCE CORPORATION	225 Bush St FL 7	San Francisco	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	002	6	6/2/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$366,656
2016	2016	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	001	5	6/2/2016	NON-COMPETING CONTINUATION	-$366,656
2016	2016	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	5	4/14/2016	NON-COMPETING CONTINUATION	$366,656
														Subtotal = $366,656

Issue Date FY: 2015 ( Subtotal = $582,196 )
2015	2015	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	4	5/15/2015	NON-COMPETING CONTINUATION	$582,196
														Subtotal = $582,196

Issue Date FY: 2014 ( Subtotal = $536,382 )
2014	2014	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	3	5/9/2014	COMPETING CONTINUATION	$536,382
														Subtotal = $536,382

Grand Total All Awards = $1,496,936

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Computerized Social Cognition training for Schizophrenia

Award Number: R44MH091793

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/05/2011

PERIOD OF PERFORMANCE END DATE: 05/02/2016

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