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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MRI

Award Number: R44MH086984
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2019

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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MRI - Summary The long term objective of the project is to implement new motion robust magnetic resonance imaging (MRI) technology into wide clinical and research use. Magnetic resonance imaging is a powerful tool that aids in the diagnosis of individual subjects, guides their clinical care, and provides insights into the mechanisms of normal and atypical development. The characterization of mental health disorders across the lifespan has been facilitated by brain MRI. However, conventional magnetic resonance imaging requires the subject being imaged remain perfectly still for the duration of the image encoding. Young children and non-cooperative adult patients have difficulty to hold still long enough for successful imaging. For clinical imaging such patients are frequently sedated or anesthetized, which runs the risk of adverse events, is costly, and does not ensure the subjects remain perfectly still. Research studies are typically unable to use sedation or anesthesia due to its significant risk. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The ability to use routinely motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions. The project proposes to utilize a combination of hardware for prospective motion tracking during scan and post-acquisition processing to enable the construction of high resolution and high signal-to-noise ratio images of the brain from subjects who are unable to hold still. The specific aims of this Phase IIB SBIR application are to optimize the EndoScout configuration and workflow for routine clinical and research use; to implement of the hybrid prospective/re-acquisition/retrospective framework into a wide scale clinical and research use; and to develop new, sophisticate motion correction approaches. This is a joint project by Robin Medical, Inc., which will optimize the motion tracking system for routine clinical and human research use; the Research Section at the Department of Radiology, Children’s Hospital Boston, which will implement the prospective motion correction algorithm into wide range of imaging sequences and will conduct the clinical studies of the project; and the Martinos Center at the Massachusetts General Hospital that will develop advanced sequences for prospective motion correction, using the EndoScout tracking data along with image navigators, and will use the motion immune MRI sequences in ongoing human research studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $798,308 )
2018	2018	ROBIN MEDICAL, INC.	3502 GARDENVIEW RD	PIKESVILLE	MD	21208	BALTIMORE	USA	Mental Health Research Grants	001	8	9/13/2018	NON-COMPETING CONTINUATION	$798,308
2018	2017	ROBIN MEDICAL, INC.	3502 GARDENVIEW RD	PIKESVILLE	MD	21208	BALTIMORE	USA	Mental Health Research Grants	000	7	8/27/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $798,308

Issue Date FY: 2017 ( Subtotal = $786,181 )
2017	2017	ROBIN MEDICAL, INC.	3502 GARDENVIEW RD	PIKESVILLE	MD	21208	BALTIMORE	USA	Mental Health Research Grants	000	7	9/7/2017	NON-COMPETING CONTINUATION	$786,181
														Subtotal = $786,181

Issue Date FY: 2016 ( Subtotal = $798,308 )
2016	2016	ROBIN MEDICAL, INC	6607 BONNIE RIDGE DRIVE	BALTIMORE	MD	21209	BALTIMORE CITY	USA	Mental Health Research Grants	000	6	9/23/2016	COMPETING CONTINUATION	$798,308
														Subtotal = $798,308

Grand Total All Awards = $2,382,797

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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MRI

Award Number: R44MH086984

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2019

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