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AUTOMATED BRAIN PARCELLATION AND MORPHOMETRY

Award Number: R44MH070515
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2002
PERIOD OF PERFORMANCE END DATE: 08/31/2005

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AUTOMATED BRAIN PARCELLATION AND MORPHOMETRY - DESCRIPTION (provided by applicant): Neurodegenerative disorders, psychiatric disorders, and healthy aging are all are frequently associated with structural changes in the brain These changes can cause alterations in the imaging properties of brain tissue, as well as changes in morphometric properties of the brain, such as volume, folding and surface area Current analysis techniques require extensive manual intervention by a skilled operator, and in addition are highly sensitive to the pulse sequence and scanner that is used to obtain the data The ultimate goal of this project is to develop a set of automated tools for exhaustive labeling of the cerebral volume (cortical and sub cortical) to identify disease-specific changes related to neurodegenerative disorders such as Alzheimer's disease These procedures are based on intrinsic properties of brain tissue, therefore they will function reliably on MRI datasets regardless of the pulse sequence or manufacturer of the scanner from which they were originally obtained. The proposed software is designed to lead to substantial improvement over current methods for automated quantification of brain morphology These segmentation procedures will be commercialized as a novel image processing service for clinical drug trials and large multi-center research studies utilizing an integrated software pipeline that is robust, scalable, rapid and highly automatic Additionally this technology will be implemented as plug-in software that may be embedded within a MRI scanner's operating system to provide these quantification technologies to clinical users.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $347,239 )
2004	2004	CORTECHS LABS INC	6 13TH STREET	CHARLESTOWN	MA	02129	SUFFOLK	USA	Mental Health Research Grants	000	3	7/14/2004	NON-COMPETING CONTINUATION	$347,239
														Subtotal = $347,239

Issue Date FY: 2003 ( Subtotal = $449,513 )
2003	2003	CORTECHS LABS INC	6 13TH STREET	CHARLESTOWN	MA	02129	SUFFOLK	USA	Mental Health Research Grants	000	2	9/1/2003	OTHER REVISION	$449,513
														Subtotal = $449,513

Grand Total All Awards = $796,752

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AUTOMATED BRAIN PARCELLATION AND MORPHOMETRY

Award Number: R44MH070515

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2002

PERIOD OF PERFORMANCE END DATE: 08/31/2005

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