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PINPOINT: Gaming technology to engage adolescent sickle cell patients in precision pain Phase I

Award Number: R44MD010746
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/12/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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PINPOINT: Gaming technology to engage adolescent sickle cell patients in precision pain Phase I - Sickle cell disease (SCD) is the most common inherited blood disorder in the U.S. and disproportionately affects African Americans and Hispanics. Approximately, 1,000 U.S. children are born with SCD annually. SCD results from abnormal hemoglobin and causes red blood cells (RBCs) to become misshaped (“sickle-shaped”). Sickled cells can block the flow of blood in small arteries causing tissue and organ damage and other life- threatening comorbidities. SCD complications can be serious and have a significant impact upon well-being and quality of life. Pain is the hallmark symptom associated with SCD, and is the most common clinical problem seen in children and the number one cause of SCD-related hospital admissions. If left untreated, these painful episodes can result in morbidity and mortality. Accurate assessment of pain specifiers (type, frequency, and intensity of pain) can help with ameliorating pain quickly and effectively. Despite children being accurate self-reporters of their pain, strategies which are effective and engaging to assist with pain identification and communication of pain are lacking. In a Phase I SBIR, our team examined the feasibility and acceptability of a gamified tablet application (Pinpoint) intended to encourage teens to talk about and assess their SCD pain. The Phase I specific aims were : (1) work with an Expert Advisory Board (EAB) of experts to develop a new pain assessment tool (PAT) to engage adolescent SCD patients, improve pain specification by patients, and improve pain management by clinicians; (2) conduct cognitive interviews and focus groups with 13-17 year old SCD patients to guide and refine development of app content, design, and aesthetics to fully develop a functioning prototype; (3) conduct usability testing with 13-17 year old SCD patients to assess functionality, navigation, and satisfaction; (4) conduct cognitive interviews with medical providers to provide input on app content, perceived barriers to use, and its potential for clinical use and integration to inform future implementation; and (5) develop a specifications document to outline the Phase II development plan. Deliverables were met and feasibility was confirmed by the EAB. The proposed Phase II project will (1) develop a fully programmed, interactive Pinpoint app consisting of 5 modules addressing pain identification and communication; (2) conduct usability testing of Pinpoint to evaluate the user interface, ease of use, and perceived barriers in order to optimize the app prior to large scale evaluation (n=14); and (3) test the full app with 13-17 year olds with SCD (n=100) using a within-subjects design to evaluate changes in (a) knowledge acquisition for communicating about pain and types of pain; (b) the Pain Assessment; (c) SCD general knowledge and self- efficacy; (d) family cohesion; and (e) app usage. Overall, the proposed project has the potential to significantly impact the health of SCD teens by providing important skill acquisition for communicating about and identifying pain. This project is innovative and timely. Pinpoint will be the first tablet app to identify and translate specific pain types for SCD into a gamified app using applied gamification principles.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$10 )
2023	2019	KLEIN BUENDEL, INC.	1667 COLE BLVD	LAKEWOOD	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	000	3	1/25/2023	NON-COMPETING CONTINUATION	-$10
														Subtotal = -$10

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	KLEIN BUENDEL, INC	1667 COLE BLVD STE 225	GOLDEN	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	001	3	8/17/2021	NON-COMPETING CONTINUATION	$0
2021	2019	KLEIN BUENDEL, INC	1667 COLE BLVD STE 225	GOLDEN	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	000	3	5/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $631,577 )
2019	2019	KLEIN BUENDEL, INC	1667 COLE BLVD STE 225	GOLDEN	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	001	3	5/28/2019	NON-COMPETING CONTINUATION	$631,577
2019	2018	KLEIN BUENDEL, INC	1667 COLE BLVD STE 225	GOLDEN	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	000	2	10/31/2018	COMPETING CONTINUATION	$0
														Subtotal = $631,577

Issue Date FY: 2018 ( Subtotal = $700,201 )
2018	2018	KLEIN BUENDEL, INC	1667 COLE BLVD STE 225	GOLDEN	CO	80401	JEFFERSON	USA	Minority Health and Health Disparities Research	000	2	9/19/2018	COMPETING CONTINUATION	$700,201
														Subtotal = $700,201

Grand Total All Awards = $1,331,768

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PINPOINT: Gaming technology to engage adolescent sickle cell patients in precision pain Phase I

Award Number: R44MD010746

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/12/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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