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Novel Device to Optimize Aerosol Drug Delivery for Pulmonary Hypertension Treatment

Award Number: R44HL154960
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Novel Device to Optimize Aerosol Drug Delivery for Pulmonary Hypertension Treatment - Abstract Aerosol inhalation therapy is one of the cornerstones of respiratory therapy. The size of airborne particles determines their deposition pattern within the lungs and therefore, the efficacy of inhalation therapy. In this Phase 2 SBIR project, BridgeSource Medical (BSM) proposes to develop a breath-adaptive nebulizer with variable aerosol droplet sizes and actuation times. This can be used to administer precise doses of pharmaceutical drugs to the pulmonary system with much greater efficiency than currently available aerosol delivery devices like small-volume adaptive aerosol delivery (AAD) nebulizers that require strict patient breath timing, but do not vary droplet size. The nebulizer would be particularly beneficial in the administration of medications to treat elderly patients with respiratory conditions such as pulmonary hypertension, where long treatment times and strict requirements on patient breathing lead to poor compliance. The ultimate goal will be to develop a clinical tool that would be approved by the Food and Drug Administration (FDA) as an effective system to nebulize several drug formulations targeted for patients who cannot easily comply with strict breathing maneuvers, such as the those with advanced lung disease such as pulmonary hypertension.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	000	3	2/27/2026	NON-COMPETING CONTINUATION	$0
2026	2024	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	001	3	9/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	001	3	8/8/2025	NON-COMPETING CONTINUATION	$0
2025	2023	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	000	2	8/8/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $875,246 )
2024	2024	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	000	3	8/30/2024	NON-COMPETING CONTINUATION	$875,246
														Subtotal = $875,246

Issue Date FY: 2023 ( Subtotal = $1,013,092 )
2023	2023	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Lung Diseases Research	000	2	8/23/2023	COMPETING CONTINUATION	$1,013,092
														Subtotal = $1,013,092

Grand Total All Awards = $1,888,338

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Novel Device to Optimize Aerosol Drug Delivery for Pulmonary Hypertension Treatment

Award Number: R44HL154960

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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