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Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning

Award Number: R44HL152825
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/17/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning - Project Summary/Abstract Minnesota HealthSolutions (MHS) proposes a Phase II project to develop and validate a software product capable of automatically detecting and staging pulmonary embolisms (PEs) using clinically routine pulmonary CT angiograms (CTAs). The proposed system will combine state-of-the-art machine learning methods and the clinical expertise at Duke University into a system that integrates seamlessly into the Radiology workﬂow and standard patient care path to improve the treatment decisions of physicians in the emergency department. Pulmonary embolism is the third most common cause of death in hospital patients with an estimated incidence of 1 per 1,000 patients. CTAs are routinely used to detect PE today; however, there is signiﬁcant variability in the detection rate among radiologists using CTA. Furthermore, despite the strong evidence that the RV/LV ratio is an important clinical biomarker it is rarely measured quantitatively in practice. A successful completion of this project would provide a workﬂow-integrated tool capable of faster PE detection and more accurate staging of right heart strain to guide the physician’s treatment decision.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	MINNESOTA HEALTHSOLUTIONS CORPORATION	861 E HENNEPIN AVE	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	3	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	MINNESOTA HEALTHSOLUTIONS CORPORATION	861 E HENNEPIN AVE	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	3	2/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $935,869 )
2023	2023	MINNESOTA HEALTHSOLUTIONS CORPORATION	861 E HENNEPIN AVE STE 440	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	001	3	2/1/2023	NON-COMPETING CONTINUATION	$935,869
2023	2022	MINNESOTA HEALTHSOLUTIONS CORPORATION	861 E HENNEPIN AVE STE 440	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	2	10/20/2022	COMPETING CONTINUATION	$0
														Subtotal = $935,869

Issue Date FY: 2022 ( Subtotal = $1,018,633 )
2022	2022	MINNESOTA HEALTHSOLUTIONS CORPORATION	861 E HENNEPIN AVE STE 440	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	2	2/17/2022	COMPETING CONTINUATION	$1,018,633
														Subtotal = $1,018,633

Grand Total All Awards = $1,954,502

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Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning

Award Number: R44HL152825

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/17/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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