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Native Hemodynamic Measurement as Feedback Control for Mechanical Cardiac Support

Award Number: R44HL145847
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/03/2019
PERIOD OF PERFORMANCE END DATE: 06/14/2026

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Native Hemodynamic Measurement as Feedback Control for Mechanical Cardiac Support - Abstract Temporary Mechanical Circulatory Support (MCS) devices have been an effective means of temporary support in patients for two indications: acute myocardial infarction (MI) with or without cardiogenic shock (CS), and acute decompensated heart failure (HF). These ailments strike the elderly the hardest and are simultaneously more prevalent as age progresses. Cardiogenic shock after MI is more common in elderly patients than in the young, and HF has increasing prevalence with age (60-79, 6% have HF, for over 80, 10% have HF). In these patients, a short- term MCS device is a catheter delivered pump that can be placed in the LV, and pump blood across the aortic valve, to help maintain forward flow while unloading the failing heart. The key metric for optimizing the use of these devices includes a combination of pressure, and volume measurement. While pressure is already commonly measured on-device, MCS devices on the market today cannot estimate the total Cardiac Output of the heart, a key component of Cardiac Power Output (CPO, CO x mean aortic pressure) which is now well accepted as the single most important correlate of mortality in cardiogenic shock. Optimization of ongoing treatment as well as when to wean the patient from the MCS device to transition them to recovery (or a more permanent device) currently lacks a real-time, accurate measure of CO (necessary to calculate CPO). We propose integrating a proven LV volume measurement (admittance-based technology) capable of determining CO directly onto the MCS device, allowing the device to actively change pump speed (and therefore effect CPO) to respond to changing patient condition. In this phase 2 effort, BridgeSource Medical will demonstrate how admittance-based technology can be redeveloped for application on existing MCS device platforms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Cardiovascular Diseases Research	000	3	4/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,189,622 )
2023	2023	BRIDGESOURCE MEDICAL, CORP.	3301 NORTHLAND DR STE 214	AUSTIN	TX	78731	TRAVIS	USA	Cardiovascular Diseases Research	000	3	6/23/2023	NON-COMPETING CONTINUATION	$1,189,622
														Subtotal = $1,189,622

Issue Date FY: 2022 ( Subtotal = $498,595 )
2022	2022	BRIDGESOURCE MEDICAL, CORP.	8501 ROCKWOOD LN	AUSTIN	TX	78757	TRAVIS	USA	Cardiovascular Diseases Research	000	2	6/14/2022	COMPETING CONTINUATION	$498,595
														Subtotal = $498,595

Grand Total All Awards = $1,688,217

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Native Hemodynamic Measurement as Feedback Control for Mechanical Cardiac Support

Award Number: R44HL145847

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/03/2019

PERIOD OF PERFORMANCE END DATE: 06/14/2026

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