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Catechol-functionalized Coatings for Medical Devices

Award Number: R44HL093928
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2008
PERIOD OF PERFORMANCE END DATE: 02/28/2016

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Catechol-functionalized Coatings for Medical Devices - DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX- 72 and HDPE, opening the way to enhanced device properties for these materials. In Phase I, catechols were incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols had previously been attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. In Phase II, the catechol-functionalized polymers will be optimized, applied to two commercial medical devices (cardiovascular radial introducer and a cerebrospinal shunt) that lack adherent coatings, and expanded to include hemocompatible, passivating, and non-oxidant reliant copolymers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	INNOVATIVE SURFACE TECHNOLOGIES INC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Cardiovascular Diseases Research	000	3	2/4/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $416,784 )
2013	2013	INNOVATIVE SURFACE TECHNOLOGIES INC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Cardiovascular Diseases Research	000	3	2/21/2013	NON-COMPETING CONTINUATION	$416,784
														Subtotal = $416,784

Issue Date FY: 2012 ( Subtotal = $582,323 )
2012	2012	INNOVATIVE SURFACE TECHNOLOGIES INC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Cardiovascular Diseases Research	000	2	3/5/2012	COMPETING CONTINUATION	$582,323
														Subtotal = $582,323

Grand Total All Awards = $999,107

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Catechol-functionalized Coatings for Medical Devices

Award Number: R44HL093928

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2008

PERIOD OF PERFORMANCE END DATE: 02/28/2016

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