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STENT COATING TO PREVENT RESTENOSIS AND SUBACUTE THROMBOSIS

Award Number: R44HL090087
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2008
PERIOD OF PERFORMANCE END DATE: 07/31/2010

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STENT COATING TO PREVENT RESTENOSIS AND SUBACUTE THROMBOSIS - DESCRIPTION (provided by applicant): This fast track SBIR application proposes the refinement and preclinical testing of a coating designed to inhibit restenosis and thrombosis in intravascular stents. The research plan will build on encouraging results from pilot animal studies with coated prototypes. During Phase I, the coating process will be optimized by thoroughly analyzing system variables and verifying coating properties in each step of the coating application. Preliminary biocompatibility testing will be conducted, to identify local effects of the coating on blood and tissue. Upon meeting defined process requirements and biocompatibility requirements, the project will move to Phase II, where the coating process will be implemented in an automated, controlled application apparatus. The coated stents will undergo extensive durability testing. Animal studies are planned that will investigate the activity of the stent in an isolated vessel model. Finally, the stents will be evaluated in a 28-day porcine implant model. The coating is designed as a stand-alone solution to improve stent performance; however, the coating can be combined readily with other coatings or drug-release agents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $457,396 )
2009	2009	ACCORD BIOMATERIALS INC	3550 WEST LIBERTY	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	002	4	8/12/2009	NON-COMPETING CONTINUATION	$457,396
2009	2008	ACCORD BIOMATERIALS INC	3550 WEST LIBERTY	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	001	3	3/6/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$419,141
2009	2008	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	2	3/6/2009	EXTENSION WITH OR WITHOUT FUNDS	-$419,141
														Subtotal = $457,396

Issue Date FY: 2008 ( Subtotal = $419,141 )
2008	2008	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	2	8/28/2008	EXTENSION WITH OR WITHOUT FUNDS	$419,141
														Subtotal = $419,141

Issue Date FY: 2007 ( Subtotal = $159,618 )
2007	2007	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	1	8/16/2007	NEW	$159,618
														Subtotal = $159,618

Grand Total All Awards = $1,036,155

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STENT COATING TO PREVENT RESTENOSIS AND SUBACUTE THROMBOSIS

Award Number: R44HL090087

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2008

PERIOD OF PERFORMANCE END DATE: 07/31/2010

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