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NOVEL ALGORITHMS AND DEVICE FOR QUANTIFICATION OF WAKE-SLEEP STATES

Award Number: R44HL078442
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/27/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2011

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NOVEL ALGORITHMS AND DEVICE FOR QUANTIFICATION OF WAKE-SLEEP STATES - DESCRIPTION (provided by applicant): The overall goal of this project is to develop the means (hardware, algorithm, electrode attachments) for a fundamentally improved method for long-term monitoring of sleep architecture and quality, as well as daytime sleepiness. The device that will be developed in this project, (referred to as NeuroLOG"), will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. Chronic insomnia affects 10-15% of adults (with a prevalence of 57% in non-institutionalized elderly persons), and an additional 25 to 35 percent of adults have transient or occasional insomnia. Insomnia is associated with significant personal and socioeconomic burden, and is largely under- recognized and inadequately or inappropriately treated (including overmedication). The specific aim of the project is to develop NeuroLOG as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night- time sleep, and daytime sleepiness, and for use in the patients' normal home environment. NeuroLOG will take advantage of the novel algorithms for quantifying wake-sleep transitions that was developed in Phase I. The device will undergo extensive clinical evaluation and validation with normal subjects as well as patients with insomnia. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression. PUBLIC HEALTH RELEVANCE: The device that will be developed in this project (NeuroLOG") will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. NeuroLOG will be developed as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night-time sleep, and daytime sleepiness, and for use in the patients' normal home environment. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $642,779 )
2010	2010	NEURO WAVE SYSTEMS	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Cardiovascular Diseases Research	000	3	8/18/2010	NON-COMPETING CONTINUATION	$642,779
														Subtotal = $642,779

Issue Date FY: 2009 ( Subtotal = $604,356 )
2009	2009	NEURO WAVE SYSTEMS	4415 EUCLID AVENUE	CLEVELAND	OH	44103	CUYAHOGA	USA	Cardiovascular Diseases Research	000	2	8/25/2009	COMPETING CONTINUATION	$604,356
														Subtotal = $604,356

Grand Total All Awards = $1,247,135

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NOVEL ALGORITHMS AND DEVICE FOR QUANTIFICATION OF WAKE-SLEEP STATES

Award Number: R44HL078442

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/27/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2011

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