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LATENT REACTIVE GROUPS FOR BIOMATERIALS

Award Number: R44HL066933
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/01/2000
PERIOD OF PERFORMANCE END DATE: 01/31/2006

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LATENT REACTIVE GROUPS FOR BIOMATERIALS - DESCRIPTION (provided by applicant): Materials have been developed with bulk physical properties needed for medical devices functioning in the human body. Major emphasis is now being placed on surface chemistry for implantable medical devices to provide biocompatibility with the living tissue and lubricity for safety and ease of implantation. Radical-based surface modification has been developed to the point of rapid growth in commercial availability (PhotoLink coatings based on triplet carbonyl photochemistry). These surface modification energy sources are not effective for the inner surfaces of "opaque" medical devices such as central venous access and hemodialysis catheters and hollow fiber membranes. This project is designed to further develop latent-reactive radical generators activatible with thermal energy, which readily penetrates these "opaque" medical devices. The Phase II aims include optimization of the new reagents of Phase I, for bonding hydrophilic blood compatible polymers to biomaterials (e.g. polypropylene, polyurethane, silicone rubber). The use of these new heterobifunctional reagents will be demonstrated for 1) incorporating into the soluble polymer derivative followed by thermo chemical coupling to the surface and 2) activating the biomaterial surface, followed by coupling to soluble polymer derivatives. This innovative approach to activation of radical generators is expected to facilitate the surface modification of "inert" medical devices, which cannot be activated with long-wavelength photons for external light sources.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $376,644 )
2005	2005	INNOVATIVE SURFACE TECHNOLOGIES LLC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Cardiovascular Diseases Research	000	3	1/7/2005	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$376,644
														Subtotal = $376,644

Issue Date FY: 2003 ( Subtotal = $366,024 )
2003	2003	SURMODICS, INC	9924 WEST 74TH STREET	EDEN PRAIRIE	MN	55344	HENNEPIN	USA	Cardiovascular Diseases Research	000	2	6/30/2003	COMPETING CONTINUATION	$366,024
														Subtotal = $366,024

Grand Total All Awards = $742,668

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LATENT REACTIVE GROUPS FOR BIOMATERIALS

Award Number: R44HL066933

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/01/2000

PERIOD OF PERFORMANCE END DATE: 01/31/2006

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