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RELIABLE AND ROBUST ECG GATING SIGNAL FOR CARDIAC MR IMAGING

Award Number: R44HL066791
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/01/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2012

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RELIABLE AND ROBUST ECG GATING SIGNAL FOR CARDIAC MR IMAGING - DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) has become the gold standard for the quantitative assessment of cardiac structure and function. The key to imaging the moving myocardium is a reliable and robust electrocardiogram signal which, used as a "trigger," can provide images at specified phases throughout the cardiac cycle. Stronger field strength magnets, greater magnetic gradient slew rates, and an ever increasing number of magnetic gradient pulse sequences such as those that provide cardiac perfusion have significantly increased the difficulties of triggering. In addition, individuals with sick hearts may have abnormal ECGs. The focus of this Phase II project is to research, develop and clinically evaluate our innovative real-time, reliable and robust system for ECG triggering during cardiac MR imaging. The project has four specific aims. The first three, aimed at developing an effective MR ECG triggering system, are: 1) to optimize the Phase I prototype MRI ECG data acquisition, fiberoptic transmission system; 2) to optimize, evaluate and test our adaptive noise cancellation methods to remove the RF and magnetic gradient artifacts that overwhelm ECG detection, and 3) to develop a "real-time" embedded computer ECG trigger system and integrate it into a cardiovascular MR imaging system. Our last specific aim is to clinically analyze and evaluate the effectiveness of our MRI ECG trigger system. Our preliminary results illustrate the effectiveness of our methods in reliably detecting the ECG during MR imaging. Our methods include generating a novel optimal ECG vector for detection, and applying effective adaptive noise cancellation methods to extract the ECG R-wave from RF and gradient artifacts. Additional preliminary data demonstrates the capability of our optical telemetry system to transmit the ECG from the magnet and mitigate against the MR artifacts which corrupt the ECG signal. During Phase II, we will evaluate the performance of our triggering system using normal human subjects and a recorded data base of ECG arrhythmias and other defects. Our approach should provide a reliable and robust ECG trigger with minimal delay from the onset of the R-wave. Such a trigger would minimize blurring artifacts from cardiac and respiratory motion and improve MR tagging studies. KEYWORDS: Cardiac Magnetic Resonance Imaging, Magnetic Resonance ECG Triggering (Gating), ECG detection, cardiac imaging (MRI).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2008	PERINATRONICS MEDICAL SYSTEM, INC	1703 PEARTEE LANE	CROFTON	MD	21114	ANNE ARUNDEL	USA	Cardiovascular Diseases Research	000	4	12/23/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2008	PERINATRONICS MEDICAL SYSTEM, INC	1703 PEARTEE LANE	CROFTON	MD	21114	ANNE ARUNDEL	USA	Cardiovascular Diseases Research	000	4	3/4/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $864,070 )
2008	2008	PERINATRONICS MEDICAL SYSTEM, INC	1703 PEARTEE LANE	CROFTON	MD	21114	ANNE ARUNDEL	USA	Cardiovascular Diseases Research	000	4	7/22/2008	NON-COMPETING CONTINUATION	$864,070
														Subtotal = $864,070

Issue Date FY: 2007 ( Subtotal = $836,174 )
2007	2007	PERINATRONICS MEDICAL SYSTEM, INC	1703 PEARTEE LANE	CROFTON	MD	21114	ANNE ARUNDEL	USA	Cardiovascular Diseases Research	000	3	6/22/2007	NON-COMPETING CONTINUATION	$836,174
														Subtotal = $836,174

Issue Date FY: 2006 ( Subtotal = $904,434 )
2006	2006	PERINATRONICS MEDICAL SYSTEM, INC	1703 PEARTEE LANE	CROFTON	MD	21114	ANNE ARUNDEL	USA	Cardiovascular Diseases Research	000	2	9/29/2006	COMPETING CONTINUATION	$904,434
														Subtotal = $904,434

Grand Total All Awards = $2,604,678

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RELIABLE AND ROBUST ECG GATING SIGNAL FOR CARDIAC MR IMAGING

Award Number: R44HL066791

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/01/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2012

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