Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria

Award Number: R44HD118842
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria - Abstract - Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria Syntis Bio is developing Syn-202, a novel methionine gamma-lyase (MGL) enzyme therapy aimed at correcting the metabolic dysregulation in Homocystinuria (HCU), a rare pediatric disorder caused by mutations in the cystathionine-β-synthase (CBS) enzyme. This genetic defect leads to the toxic accumulation of methionine and homocysteine, disrupting critical metabolic pathways and resulting in severe neurological symptoms, developmental impairments, and life-threatening metabolic crises. Current treatments, which primarily rely on dietary methionine restriction, are challenging for young children and patients in resource-limited settings to adhere to, leading to poor compliance and poor outcomes. Syn- 202 offers a more effective and patient-friendly alternative by enzymatically replicating the effects of dietary methionine restriction in a convenient oral formulation. Additionally, Syn- 202 is engineered for proteolytic and pH stability, overcoming the delivery challenges that often limit the efficacy of oral biologics, ensuring consistent and reliable activity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	SYNTIS BIO INC	135 MORRISSEY BLVD	BOSTON	MA	02125	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	2/26/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $347,016 )
2025	2025	SYNTIS BIO INC	135 MORRISSEY BLVD	BOSTON	MA	02125	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	1	9/24/2025	NEW	$0
2025	2025	SYNTIS BIO INC	135 MORRISSEY BLVD	BOSTON	MA	02125	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	9/16/2025	NEW	$347,016
														Subtotal = $347,016

Grand Total All Awards = $347,016

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria

Award Number: R44HD118842

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer