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Development of a pediatric oculomotor and vestibular normative database as an essential tool for objective evaluation of concussion and return-to-school/play

Award Number: R44HD100247
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2022

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Development of a pediatric oculomotor and vestibular normative database as an essential tool for objective evaluation of concussion and return-to-school/play - Abstract In current clinical practice, diagnosis of mild traumatic brain injury (mTBI)/concussion and decision-making regarding return-to-school/play/work rely heavily on self-reported symptoms and/or on other neurocognitive tests/assessments. These assessments require baseline testing, which is not commonly done, thus greatly limiting their usefulness. Additionally for the pediatric population, continuous and rapid brain development suggest baseline testing should be done more frequently than in adults. Therefore, there is a large unmet need for developing appropriate tools to evaluate brain dysfunction and recovery following mTBI/concussion that are not baseline dependent and take into account age-dependent maturational changes. Eye movement has been traditionally used as a non-invasive observational tool for understanding neural development. Neuro Kinetics’ FDA-cleared I-Portal® technology assesses oculomotor, vestibular, reaction time and cognitive (OVRT-C) capabilities and provides a highly accurate objective measure of neural functions and brain injury-induced disturbances. The technology consists of head mounted virtual reality goggles equipped with high speed cameras to capture eye movements, a battery of specific OVRT-C tests that probe different parts of the brain and a software platform, called VESTTM, that uses sophisticated algorithms to provide OVRT-C parameters that quantify neural performance. This application seeks funding for extending the applicability of this technology to the pediatric population. Phase I of the application is to develop a new child prototype goggle and age appropriate software instructions, design and algorithms. Phase II is to collect normative OVRT-C data from healthy males and females, ages 8 to 18. This database will reflect normal development as reported by the OVRT-C tests and will serve as a tool for evaluating effects of mTBI/concussions, monitoring recovery and aiding in the return-to-school/play decision. Additionally, it can serve as an objective screening tool for mental health and neurological conditions that start early in childhood, as well as for assessing treatment efficacy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$11,790 )
2023	2019	NEURO KINETICS, INC.	128 GAMMA DR	PITTSBURGH	PA	15238	ALLEGHENY	USA	Child Health and Human Development Extramural Research	000	1	9/28/2023	NEW	-$11,790
														Subtotal = -$11,790

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	NEURO KINETICS, INC.	128 GAMMA DR	PITTSBURGH	PA	15238	ALLEGHENY	USA	Child Health and Human Development Extramural Research	000	1	9/16/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	NEURO KINETICS, INC.	128 GAMMA DR	PITTSBURGH	PA	15238	ALLEGHENY	USA	Child Health and Human Development Extramural Research	001	1	4/23/2020	NEW	$224,999
2020	2019	NEURO KINETICS, INC.	128 GAMMA DR	PITTSBURGH	PA	15238	ALLEGHENY	USA	Child Health and Human Development Extramural Research	000	1	4/21/2020	NEW	-$224,999
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $224,999 )
2019	2019	NEURO KINETICS, INC.	128 GAMMA DR	PITTSBURGH	PA	15238	ALLEGHENY	USA	Child Health and Human Development Extramural Research	000	1	8/30/2019	NEW	$224,999
														Subtotal = $224,999

Grand Total All Awards = $213,209

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Development of a pediatric oculomotor and vestibular normative database as an essential tool for objective evaluation of concussion and return-to-school/play

Award Number: R44HD100247

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2022

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