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Glove Rehabilitation Application for Stroke Patients (GRASP)

Award Number: R44HD088189
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Glove Rehabilitation Application for Stroke Patients (GRASP) - Introduction: The Glove Rehabilitation Application for Stroke Patients (GRASP) Fast-Track SBIR program will promote recovery of hand function following stroke through an instrumented orthosis that enables functional practice of manual tasks in fun and engaging activities within a virtual environment. The effort combines patented sensor glove technology developed under the NASA space suit program with a commercial hand orthosis and modern game engine technology. GRASP will automatically assess a patient’s functional level and adapt the challenge to his/her capabilities. In each session, the system will automatically produce valid metrics of hand function, providing both patients and providers with immediate feedback on status and progress. The low-cost product will support independent home use as well as serve as part of a therapistguided in-patient, skilled nursing, outpatient, home health, or teletherapy rehabilitation program. Problem to be addressed: GRASP addresses the critical challenges of: (1) improving outcomes in hand therapy through task-directed practice and mental imagery that promote functional recovery; (2) enabling increased dosage, intensity, and duration through independent home use and teletherapy; (3) minimizing total cost of rehabilitation by reducing patient/therapist travel; and (4) improving services in underserved areas. Long-Term Goal: Improved outcomes and functional independence for patients with acquired brain injury. Phase I Summary: Phase I of the Fast-Track will produce a prototype system that consists of a sensor package and software application that permits a commercial glove orthosis to be used for practice of virtual activities of daily living (ADLs) in a compelling virtual world. A pilot study conducted by the University of Virginia (UVa), UVa HealthSouth Rehabilitation Hospital, and Continuum Home Health will investigate the primary Phase I hypothesis, which states that GRASP-generated metrics correlate significantly with accepted measures of hand function. Two Phase I case studies led by home health therapists will explore usability in the home environment and serve as pathfinders for Phase II efficacy trials. Phase II Summary: Phase II of the Fast-Track will include: (1) development of a commercial system; (2) extension of the range of hand therapy activities and expansion of virtual environments to provide an engaging and motivating experience across 8 weeks of treatment; (3) provider tools for prescribing and monitoring status/progress; and (4) teletherapy interfaces. A Phase II efficacy study will investigate improvement in standardized assessment scores and adherence for GRASP at-home therapy vs. standard care. Randomized, controlled trials will be led by UVa in partnership with HealthSouth and Continuum Home Health. Commercial Opportunity: Approximately 50% of the 800,000 individuals hospitalized due to stroke each year in the U.S. suffer from chronic deficits in hand and/or arm function [1], [2]. GRASP is poised to rapidly transition evidence-based research to market by leveraging an existing brand with well-defined distribution channels.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	BARRON ASSOCIATES, INC.	1410 SACHEM PL	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	001	3	5/15/2023	NON-COMPETING CONTINUATION	$0
2023	2019	BARRON ASSOCIATES, INC.	1410 SACHEM PL	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	000	3	5/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	BARRON ASSOCIATES, INC.	1410 SACHEM PL STE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	000	3	3/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $713,009 )
2019	2019	BARRON ASSOCIATES, INC.	1410 SACHEM PL STE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	000	3	5/1/2019	NON-COMPETING CONTINUATION	$713,009
2019	2016	BARRON ASSOCIATES, INC.	1410 SACHEM PL STE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	001	1	5/1/2019	NEW	$0
														Subtotal = $713,009

Issue Date FY: 2018 ( Subtotal = $768,524 )
2018	2018	BARRON ASSOCIATES, INC.	1410 SACHEM PL STE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	001	2	5/15/2018	EXTENSION WITH OR WITHOUT FUNDS	$768,524
2018	2016	BARRON ASSOCIATES, INC.	1410 SACHEM PL STE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	000	1	5/15/2018	NEW	$0
														Subtotal = $768,524

Issue Date FY: 2016 ( Subtotal = $224,961 )
2016	2016	BARRON ASSOCIATES, INC	1410 SACHEM PLACE, SUITE 202	CHARLOTTESVILLE	VA	22901	ALBEMARLE	USA	Child Health and Human Development Extramural Research	000	1	9/22/2016	NEW	$224,961
														Subtotal = $224,961

Grand Total All Awards = $1,706,494

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Glove Rehabilitation Application for Stroke Patients (GRASP)

Award Number: R44HD088189

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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