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New Test System for Blood Lead Levels in Children

Award Number: R44HD087097
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/22/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2019

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New Test System for Blood Lead Levels in Children - DESCRIPTION (provided by applicant): Lead exposure threatens the health of millions of children, yet it is entirely preventable health problem. Our project objective is to develop an advanced blood lead test to identify and protect those at risk through blood lead screening tests of children. Even very low lead exposure, measured by blood lead levels, causes irreversible damage, especially in very young children, resulting in decreased IQ, learning disabilities, attention deficit disorders, behavioral problems, stunted growth and other serious individual and societal problems. The US Department of Health and Human Services has established an ambitious goal of eliminating lead poisoning in children. The Centers for Disease Control has lowered the level of blood lead that calls for concern down to 5 µg/dL, with predictions of settin a lower level of concern in the near future. It is generally agreed that no level of lead exposure s safe. To aid in this public health effort, we propose to develop a new, needed, clinical blood lead test. The Aims of our Phase II research and development project are to produce and validate a low- cost diagnostic product by (Aim 1) developing an innovative 8 sensor platform capable of sensor-based measurement of blood lead levels, by (Aim 2) developing the platform to meet current and emerging needs of accuracy and precision over the entire range of measurement for child tests down to blood lead levels of 1 µg/ dL using a single drop of blood, by (Aim 3) producing a new proprietary Metexchange(r) reagent, containing no toxic chemicals that effectively lyse RBC and releases Pb2+ for sensitive and accurate ASV analysis of blood lead levels over the entire clinical range, without bias to Graphite Furnace Atomic Absorption Spectroscopy (GFAAS), and by (Aim 4) validating accurate, precise and sensitive measurements of total lead levels in clinical blood specimens over the entire range, equal to or better than GFAAS. No system yet accomplishes this.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	ALDERON BIOSCIENCES, INC.	120 TURNER STREET, SUITE A	BEAUFORT	NC	28516	CARTERET	USA	Child Health and Human Development Extramural Research	000	2	2/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $554,446 )
2017	2017	ALDERON BIOSCIENCES, INC.	120 TURNER STREET, SUITE A	BEAUFORT	NC	28516	CARTERET	USA	Child Health and Human Development Extramural Research	000	2	8/18/2017	NON-COMPETING CONTINUATION	$554,446
														Subtotal = $554,446

Issue Date FY: 2016 ( Subtotal = $554,446 )
2016	2016	ALDERON BIOSCIENCES INC	2810 MERIDIAN PARKWAY STE 152	DURHAM	NC	27713	DURHAM	USA	Child Health and Human Development Extramural Research	000	1	8/19/2016	NEW	$554,446
														Subtotal = $554,446

Grand Total All Awards = $1,108,892

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New Test System for Blood Lead Levels in Children

Award Number: R44HD087097

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/22/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2019

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