High-throughput Biocatalyst Manufacturing for Environmental Biotechnology - Project Summary / Abstract
A variety of hazardous compounds continue to pose serious and widespread risks to public health and safety in
the United States. Organic compounds, in particular, such as chlorinated solvents, hydrocarbons, disinfection
byproducts, pesticides, polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and other
xenobiotic (not naturally occurring) organic chemicals comprise a major category of water contaminants. These
high-priority pollutants are often regulated by state and federal agencies due to their proven links to cancer and
various diseases, including liver or kidney disease, immune dysfunction, nervous system disorders, and
hormonal or reproductive defects. However, existing chemical, physical and biological technologies to remove
these compounds suffer from significant limitations that lead to low treatment efficiency and/or increases costs
for Superfund site managers, municipalities and water supplies.
This project is based on a prior Phase II project involving the successful development of an enhanced
cometabolism-based biological technology that significantly overcomes the limitations of conventional treatment
systems. This new technology has been demonstrated to degrades the hazardous organic compounds into
harmless byproducts instead of producing a concentrated secondary waste stream. Moreover, this new
technology offers significant reductions in energy and maintenance costs compared with chemical or UV
oxidation, and offers both an in-situ and ex-situ treatment options across a range of operating conditions to
simultaneously and cost-effectively remove hazardous organic compounds from water.
In this proposal, the manufacturing processes underlying this technology are significantly improved in terms of
manufacturing throughput, waste reduction, quality control and environmental footprint. Specifically, the existing
production process for the technology is redesigned and re-engineered using semi-automated, high-throughput
process units to optimize material usage, reduce labor costs, ensure liquid and chemical recycling and ultimately
lead to a significant reduction in manufacturing costs, thereby enhancing the widespread implementation and
availability of the treatment technology to a greater number of sites, especially disadvantaged and rural
communities which often lack the resources to address local water contaminations.
The outcome of this project is a significant advance in the versatile manufacturing of biocatalyst composites at
the heart of the treatment of hundreds of contaminants. The successful result of this project holds significant
promise in addressing harmful contaminants that are not effectively treatable using existing technologies, and
thereby recovering substantial stakeholder value for public and private stewardship of water resources.
