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ONE-STEP RAPID SCREENING FOR CHILDHOOD LEAD POISONING

Award Number: R44ES012334
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2006

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ONE-STEP RAPID SCREENING FOR CHILDHOOD LEAD POISONING - DESCRIPTION (provided by applicant): The CDC states that lead poisoning is the number one environmental health problem, affecting children in the US because it affects one of every six at-risk children and it is acknowledged to be a source of cognitive and behavioral impairment. Only 25% of the at-risk US children are tested. Atomic absorption instruments do 80% of blood lead tests in the US, but this technology is not likely to become substantially more accessible because it is limited to sophisticated labs and requires skilled operators. The objective of this proposed multi-phase project is to develop an innovative "one-step" electrochemical blood lead testing technology that will satisfy the economic, performance, and logistical needs of at-risk populations. As shown feasible in Phase I work, we will configure a sensor that will accept an unmeasured, untreated sample and an assay that will produce a quantitative blood lead result in about 3 minutes. The market-need for a one-step, CLIA waived blood lead system will increase the amount of lead testing done and ultimately lower the cost per result to < $3. We will also work to improve electrochemical blood lead analysis performance and extend the dynamic response range to meet U.S. and worldwide needs. We will incorporate instrument and sensor features that would allow users to test unmeasured and untreated whole blood and obtain an accurate, precise result. The expected result of the overall project will be technology that will allow substantially more lead testing in the United States and worldwide. Within the guidelines of permissible levels of childhood blood lead levels there are as many as 10 million children at risk, but only 2.5 million are tested. Expensive atomic absorption instruments do 2 million of these tests at a cost of $1 to $3 per reportable result. Much less expensive instruments are used for point of- care electrochemical tests but presently cost $4 to $6 per reportable result. Atomic absorption cannot easily increase the number of blood lead tests done because it is logistically inaccessible to 80% of the US target population and nearly 100% of the target international population. The genuine potential in the US blood lead market (7.5 million tests) lies with cost-effective and rapid electrochemical measurement. The proposed high-performance, low-cost electrochemical technology will be extremely competitive for the $7.5 million available US market and the potentially much larger international market.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $598,042 )
2005	2005	ALDERON BIOSCIENCES INC	2810 MERIDIAN PARKWAY STE 152	DURHAM	NC	27713	DURHAM	USA	Applied Toxicological Research and Testing	000	3	5/31/2005	NON-COMPETING CONTINUATION	$598,042
														Subtotal = $598,042

Issue Date FY: 2004 ( Subtotal = $151,957 )
2004	2004	ALDERON BIOSCIENCES INC	2810 MERIDIAN PARKWAY STE 152	DURHAM	NC	27713	DURHAM	USA	Applied Toxicological Research and Testing	000	2	9/29/2004	COMPETING CONTINUATION	$151,957
														Subtotal = $151,957

Grand Total All Awards = $749,999

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ONE-STEP RAPID SCREENING FOR CHILDHOOD LEAD POISONING

Award Number: R44ES012334

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2006

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