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Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

Award Number: R44EB035078
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform - SUMMARY/ABSTRACT In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogenous contrast imaging. Our overall approach is to improve sensitivity and resolution by minimizing distortion, adding transmit/receive channels, decoupling, improving preamplifiers, and developing new pulse sequences. MPI is an emerging molecular and tracer imaging technology that directly detects magnetic nanoparticles (MNPs) with high sensitivity at mm-scale resolutions. MPI images are direct views of tracer distribution with no signal arising from tissue, no perturbations from materials such as air, and image intensity directly linear with tracer concentration. This “hot-spot” contrast provides spatial localization and quantification without ambiguity. MPI’s contrast is similar to nuclear medicine but without the workflow, safety, and half-life limitations of a radioactive tracer. MPI has many applications in the brain and body, as demonstrated by our customers in small animals. Despite significant efforts by multiple institutions, the lack of a clinical MPI scanner remains a significant limitation for the technique. In this Direct to Phase II SBIR proposal, we will advance the medical imaging field by building the world’s first general-purpose clinical MPI scanner to serve the myriad applications our customers are testing on our preclinical instrument. We will design and implement a new transmit/receive subsystem and install it in our prototype scanner to achieve the performance necessary for clinical imaging applications. This new transmit/receive subsystem includes the following innovations that push our sensitivity from our current rough prototype to near the physics limit through the following specific aims: Aim 1. Drive transmit distortion and the noise floor to the physics limit for a one-channel Tx/Rx coil Aim 2. Design a clinical multi-channel transmit and receive subsystem Aim 3. Develop new acquisition pulse sequences to improve sensitivity, resolution, and speed


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $996,469 )
2024	2024	MAGNETIC INSIGHT, INC	2020 N LOOP RD	ALAMEDA	CA	94502	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/2/2024	NON-COMPETING CONTINUATION	$996,469
														Subtotal = $996,469

Issue Date FY: 2023 ( Subtotal = $1,008,452 )
2023	2023	MAGNETIC INSIGHT	2020 N LOOP RD	ALAMEDA	CA	94502	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/22/2023	NEW	$1,008,452
														Subtotal = $1,008,452

Grand Total All Awards = $2,004,921

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Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

Award Number: R44EB035078

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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