Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

High-resolution micro-magnetometer based on novel nano-junction oxide SQUIDs

Award Number: R44EB023147
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2023

Group Awards By:

View Award Description

High-resolution micro-magnetometer based on novel nano-junction oxide SQUIDs - This Phase II project will develop a general purpose magnetic microscope and evaluate its utility in biomedical sciences. The microscope will detect the magnetic field using high-transition temperature (high-Tc) sensors based on the superconducting quantum interference device (SQUID) developed during the Phase I. UC Riverside (UCR) has developed a novel high-Tc SQUID fabrication technique that gives a junction noise comparable to that of low-Tc SQUIDs. Their approach uses a focused helium ion beam to make the Josephson junction with 0.5 nm precision, resulting in reliable, reproducible SQUIDs with high yields. During Phase I we have designed three magnetometers based on this SQUID. We found the direct injection magnetometer to produce a junction noise of 6 µΦo/√Hz comparable with a low-Tc SQUID noise. We mounted the best one just below the window of a microscope stage in an inverted microscope and determined its field sensitivity at 13oK to be 1 pT/√Hz for an effective detector area of 62 µm radius. In Aim 1, UCR will improve the noise level further by optimizing the dimensions of the junction, the SQUID loop and the coupling efficiency with the pickup loop. UCR will construct 1x3 SQUID chips and deliver them to Tristan in year 1. Tristan, meanwhile, will design and construct an inverted SQUID microscope (iSM) based on their previous iSM. It will be equipped with an up-right fluorescent microscope above and micromanipulators for stimulator and recording electrodes on the sides. The window in the microscope stage will have a micro-channel etched inside to achieve a distance of 10-25 µm between a sample and the SQUID array for single nanoparticle and neuron detection. This very short gap is possible because the SQUIDs are high-Tc superconductors and thus they operate at >10oK. They will mount two of the test SQUID chips into a 2x3 array and evaluate their sensitivities. Once a working iSM is constructed, it will be shipped to Boston for evaluating its utility in biomedical sciences by the beginning of year 2. After shipping the iSM, UCR will continue to improve their SQUID chips. Once they achieve a significant reduction in detector noise, Boston will ship the iSM back to Tristan and Tristan will test the iSM with the improved SQUID chips. Tristan will ship back the improved iSM to Boston for continuing the evaluation. In Aim 2, Dr. Okada of Moment and Dr. Lin of Boston University (BU) will use an isolated crayfish giant axon during year 1 to develop the method for magnetic field detection from single neurons. Dr. Man of BU will develop cultured hippocampal neurons from fetal rats. In year 2, Drs. Okada and Lin will evaluate the iSM for measuring intracellular currents from single neurons. In Aim 3, Dr. Okada and Dr. Medarova of the Martinos Center at Massachusetts General Hospital will construct nanoparticles and fluorescent dye conjugated with avidin and biotin. They will magnetize the nanoparticles using an AC method and test whether the iSM can detect single complexes. This will serve as the proof of concept for future applications. The fluorescent signals from the same complex will be measured with the optical microscope for comparative studies. Phase II deliverables – the iSM, a performance report, publications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$8,276 )
2024	2019	TRISTAN TECHNOLOGIES, INC.	8860 KENAMAR DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/13/2024	NON-COMPETING CONTINUATION	-$8,276
														Subtotal = -$8,276

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	9/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	9/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $497,340 )
2019	2019	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	8/28/2019	NON-COMPETING CONTINUATION	$497,340
2019	2018	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	10/30/2018	COMPETING CONTINUATION	$0
														Subtotal = $497,340

Issue Date FY: 2018 ( Subtotal = $996,615 )
2018	2018	TRISTAN TECHNOLOGIES, INC.	6191 CORNERSTONE CT E STE 107	SAN DIEGO	CA	92121	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	9/21/2018	COMPETING CONTINUATION	$996,615
														Subtotal = $996,615

Grand Total All Awards = $1,485,679

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-resolution micro-magnetometer based on novel nano-junction oxide SQUIDs

Award Number: R44EB023147

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer