Saturday, June 7, 2025 6/7/2025

A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging

Award Number: R44EB021125
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging - ¿ DESCRIPTION (provided by applicant): X-ray tricontrast imaging provides three different modes of contrast: absorption contrast (the mechanism behind how conventional medical X-ray imaging equipment images), phase contrast (which provides up to 1000X more contrast than absorption-based contrast for soft tissue), and scatter contrast (which provides information of features at dimensions smaller than the resolution of absorption and phase contrast). Access to all three contrast modes is widely considered one of the most exciting developments in modern X-ray physics, and has significant potential to change the face of biomedical imaging for early detection of cancer, osteoarthritis, and other soft tissue diseases. The recent development of Talbot-Lau interferometry, a grating- based technique that uses three gratings to achieve tricontrast imaging, has high potential to achieve tricontrast imaging in clinical use. However, there are several major limitations stemming from the use of two out of the three gratings. These two gratings are not entirely necessary and the removal of the gratings would still allow the technique to work, as long as substantial innovation is made to the source and to the detector. We propose to develop a high detective quantum efficiency (DQE) microstructured detector with good resolution to enable clinical Talbot interferometers without need of one of the two problematic gratings. The other grating may be removed by innovation on the source, for which we have also devised a proposal that has previously been submitted to the NIH and is awaiting a final funding decision (it received an outstanding impact score of 20). The proposed Phase I 6-month project is a proof-of-principle demonstration that the microstructured detector can be manufactured and would provide high detective quantum efficiency, and the proposed Phase II 24-month project would produce working prototypes of the detector.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	8/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = -$164 )
2018	2015	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/17/2018	NEW	-$145
2018	2015	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	9/17/2018	SUPPLEMENT FOR EXPANSION	-$19
														Subtotal = -$164

Issue Date FY: 2017 ( Subtotal = $719,633 )
2017	2017	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	8/14/2017	NON-COMPETING CONTINUATION	$719,633
														Subtotal = $719,633

Issue Date FY: 2016 ( Subtotal = $780,271 )
2016	2016	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	9/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$0
2016	2016	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	9/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$780,271
														Subtotal = $780,271

Issue Date FY: 2015 ( Subtotal = $246,990 )
2015	2015	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	8/28/2015	SUPPLEMENT FOR EXPANSION	$29,000
2015	2015	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/20/2015	NEW	$217,990
2015	2015	SIGRAY INC	151 ADAMS RANCH ROAD	WALNUT CREEK	CA	94595	CONTRA COSTA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	8/26/2015	NEW	$0
														Subtotal = $246,990

Grand Total All Awards = $1,746,730

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging

Award Number: R44EB021125

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer