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MRI-ENHANCED ENDOSCOPY WITH TRACKING-IMAGING PROBES

Award Number: R44EB001483
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2003
PERIOD OF PERFORMANCE END DATE: 08/31/2009

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MRI-ENHANCED ENDOSCOPY WITH TRACKING-IMAGING PROBES - DESCRIPTION (provided by applicant): The Phase-II project aims to develop tracking and imaging probe (TIP) for MR-enhanced endoscopy. MRI has many advantages over traditional optical and ultrasound endoscopy, such as excellent soft tissue contrast and temperature-sensitive imaging. The use of Robin Medical's proprietary tracking technology with local imaging will enable high-resolution MR imaging during endoscopy and is expected to improve the yield of endoscopic interventions, for example by replacing open surgery with image-guided, minimally-invasive endoscopy. The specific aims of Phase-2 are: To develop the final configuration of the TIP; To integrate the TIP into MR-compatible endoscopes; To conduct animal studies for safety assessment and to evaluate the performance of the system in-vivo; To conduct pilot human studies to demonstrate the clinical efficacy of MR-aided endoscopy. The TIP, an innovative hollow probe that enables tracking and imaging, will be integrated into the tip of MR-compatible endoscope. Matching and tuning circuitry will be developed to interface the TIP to standard MR scanners. The animal studies will include temperature monitoring of the endoscope during MRI, imaging normal wall, imaging wall structure following induction of lesions, and imaging effect of cryotherapy. Limited series of human endoscopy procedures will compare polyp structure by MR-endoscopy to histology sections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2006	ROBIN MEDICAL, INC	3101 NORTHBROOK ROAD	BALTIMORE	MD	21208	BALTIMORE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/13/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2006 ( Subtotal = $495,153 )
2006	2006	ROBIN MEDICAL, INC	3101 NORTHBROOK ROAD	BALTIMORE	MD	21208	BALTIMORE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	8/14/2006	NON-COMPETING CONTINUATION	$495,153
														Subtotal = $495,153

Issue Date FY: 2005 ( Subtotal = $493,131 )
2005	2005	ROBIN MEDICAL, INC	3101 NORTHBROOK ROAD	BALTIMORE	MD	21208	BALTIMORE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	8/26/2005	NON-COMPETING CONTINUATION	$493,131
														Subtotal = $493,131

Issue Date FY: 2004 ( Subtotal = $518,552 )
2004	2004	ROBIN MEDICAL, INC	3101 NORTHBROOK ROAD	BALTIMORE	MD	21208	BALTIMORE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	9/16/2004	COMPETING CONTINUATION	$518,552
														Subtotal = $518,552

Grand Total All Awards = $1,506,836

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MRI-ENHANCED ENDOSCOPY WITH TRACKING-IMAGING PROBES

Award Number: R44EB001483

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2003

PERIOD OF PERFORMANCE END DATE: 08/31/2009

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