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An intravascular Bioartificial Pancreas (iBAP)

Award Number: R44DK104299
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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An intravascular Bioartificial Pancreas (iBAP) - Project Summary Approximately 3 million Americans and around 24 million people worldwide are affected by Type 1 Diabetes (T1D). Exogenous insulin injection, allogeneic whole organ pancreas transplantation, and allogeneic islet transplantation are the most common treatments for T1D. These treatments can achieve glycemic control for many patients but result in serious complications. A bioartificial pancreas is a promising treatment for T1D because it contains functional islets. However, previous attempts to develop a bioartificial device have been severely limited by insufficient mass transfer within the islet chamber. Silicon Kidney LLC has developed and is commercializing the silicon nanopore membranes (SNM) that achieves high-efficiency blood ultrafiltration while selectively retaining specific solutes. The ultra-high hydraulic permeability characteristic of the SNM will enable appropriate mass transport (especially oxygen, glucose, and insulin) within the islet chamber to achieve optimal islet performance, while the ultra-selective pore characteristic of the SNM enable unprecedented immunoprotection. The ultimate objective of this Phase IIB SBIR project is to create a clinical-scale iBAP and complete all pre-clinical testing in order to file for an IND for a future FIH clinical study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	SILICON KIDNEY LLC	255 KANSAS ST STE 300	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	8/17/2026	COMPETING CONTINUATION	$0
2026	2025	SILICON KIDNEY LLC	255 KANSAS ST STE 300	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/30/2026	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,000,000 )
2025	2025	SILICON KIDNEY LLC	255 KANSAS ST STE 300	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/22/2025	COMPETING CONTINUATION	$0
2025	2025	SILICON KIDNEY LLC	255 KANSAS ST STE 300	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/30/2025	COMPETING CONTINUATION	$1,000,000
														Subtotal = $1,000,000

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2019	SILICON KIDNEY LLC	101 MISSISSIPPI ST	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	2/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/17/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $746,229 )
2019	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94153		USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/19/2019	NON-COMPETING CONTINUATION	$746,229
														Subtotal = $746,229

Issue Date FY: 2018 ( Subtotal = $746,324 )
2018	2018	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94153		USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/11/2018	COMPETING CONTINUATION	$746,324
														Subtotal = $746,324

Grand Total All Awards = $2,492,553

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An intravascular Bioartificial Pancreas (iBAP)

Award Number: R44DK104299

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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