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An implantable hemodialyzer for treatment of End-stage Renal Disease

Award Number: R44DK102240
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2022

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An implantable hemodialyzer for treatment of End-stage Renal Disease - Project Summary End-Stage Renal Disease (ESRD) affects just over 600,000 people in the United States and costs Medicare ~$33 billion annually. In-center thrice-weekly hemodialysis is the most commonly performed treatment for ESRD, but it suffers from poor 5-year survival rates, reduced patient quality of life, and is costly. In contrast, frequent hemodialysis has demonstrated 5-year survival rates similar to kidney transplant and has improved intermediate outcomes. Even though frequent hemodialysis yields superior outcomes than in-center thrice- weekly hemodialysis, it is performed by less than 1% of the ESRD population because it is too costly to perform in-center and too complex to perform at home. Current home hemodialysis systems require patients and caregivers to perform complicated tasks associated with life threatening risks, such as self-care needle sticks. The superior outcomes but low adoption rate of frequent home hemodialysis creates an opportunity for a simple-to-use and safe home hemodialysis system. The long-term objective of our project is to create a new home hemodialysis system (the iHemo) that will increase the practice of frequent home hemodialysis and improve End-Stage Renal Disease (ESRD) outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	SILICON KIDNEY LLC	101 MISSISSIPPI ST	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $51,360 )
2020	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/10/2020	NON-COMPETING CONTINUATION	$51,360
														Subtotal = $51,360

Issue Date FY: 2019 ( Subtotal = $686,850 )
2019	2019	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94153		USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/25/2019	NON-COMPETING CONTINUATION	$686,850
														Subtotal = $686,850

Issue Date FY: 2018 ( Subtotal = $756,920 )
2018	2018	SILICON KIDNEY	1700 4TH ST ROOM 219	SAN FRANCISCO	CA	94153		USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/15/2018	COMPETING CONTINUATION	$756,920
														Subtotal = $756,920

Grand Total All Awards = $1,495,130

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An implantable hemodialyzer for treatment of End-stage Renal Disease

Award Number: R44DK102240

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2022

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