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IMPLANTABLE GLUCOSE SENSOR WITH PROLONGED ACCURACY

Award Number: R44DK074243
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2006
PERIOD OF PERFORMANCE END DATE: 08/31/2010

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IMPLANTABLE GLUCOSE SENSOR WITH PROLONGED ACCURACY - DESCRIPTION (provided by applicant): The goal of this study is to fabricate an intravascular glucose sensor that functions accurately for 7 days in vivo. We will utilize a glucose membrane design devised in Phase I to develop a custom outer membrane that has covalently attached bioactive sites to resist biofouling, allows for suitable glucose diffusion, and prevents leaching of potentially toxic by-products. This membrane will be applied to needle-type, amperometric glucose sensor. The versatility of the sensor design will allow easy incorporation into a patient's bloodstream through a central access catheter. The catheter will be designed for 7 day use in the intensive care unit, and will be complete with a hemostatic connector for attaching to an access line, and the electrical connections to an amplifier/display unit. The final prototype will be evaluated for cytotoxicity, hemocompatibilty, and accuracy both using in vitro and in vivo methods. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy. PUBLIC HEALTH RELEVANCE: The goal in this grant is to make an intravascular glucose sensor that measures blood glucose levels continuously for 7 days. By maintaining sensor function, this technology will provide health care professionals with immediate changes in patient health and decrease complications. Currently sudden changes in glucose levels are not detected leading to increased health care costs and increased risks to patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $388,052 )
2009	2009	ACCORD BIOMATERIALS INC	3550 WEST LIBERTY	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	4	9/11/2009	NON-COMPETING CONTINUATION	$388,052
2009	2008	ACCORD BIOMATERIALS INC	3550 WEST LIBERTY	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	12/3/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$418,161
2009	2008	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/3/2008	COMPETING CONTINUATION	-$418,161
														Subtotal = $388,052

Issue Date FY: 2008 ( Subtotal = $418,161 )
2008	2008	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/26/2008	COMPETING CONTINUATION	$418,161
														Subtotal = $418,161

Grand Total All Awards = $806,213

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IMPLANTABLE GLUCOSE SENSOR WITH PROLONGED ACCURACY

Award Number: R44DK074243

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2006

PERIOD OF PERFORMANCE END DATE: 08/31/2010

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