Thursday, November 21, 2024 11/21/2024

Automated Dental Fracture Detection using High Resolution CBCT and Advanced Image Analysis

Award Number: R44DE027574
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Epidemiological studies indicate that cracked teeth are the third most common cause of tooth loss in industrialized countries. Histological studies demonstrate that all cracks are colonized by bacteria, which have the potential to cause intensely painful pulpal and periapical infections. The early detection of cracks (incomplete fractures) followed by appropriate interventions to prevent crack propagation are effective strategies to prevent infections and avert tooth loss. Current tools used to diagnose cracks are inadequate and there is an imperative need to develop an objective and reliable method to detect cracks. During our Phase I project, we developed and tested a novel algorithm for crack detection on extracted human teeth. Using machine learning and imaging features extracted from three-dimensional (3D) wavelets, we demonstrated enhanced crack detection hr-CBCT. We now propose to further refine this technology and to validate it clinically. Our hypothesis is that our method increases the predictive validity of hr-CBCT in detecting cracks. This development will happen with close clinical guidance. Also, we will collaborate with CBCT hardware vendors to increase the impact of our commercialization plan. This proposal addresses the need for quantitative, reproducible, and evidence-based ways to detect cracks in teeth, that can potentially lead to improved tooth loss prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Oral Diseases and Disorders Research	000	3	7/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $844,321 )
2022	2022	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Oral Diseases and Disorders Research	001	3	8/19/2022	NON-COMPETING CONTINUATION	$844,321
2022	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Oral Diseases and Disorders Research	000	2	1/28/2022	COMPETING CONTINUATION	$0
														Subtotal = $844,321

Issue Date FY: 2021 ( Subtotal = $855,962 )
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Oral Diseases and Disorders Research	000	2	9/21/2021	COMPETING CONTINUATION	$855,962
														Subtotal = $855,962

Grand Total All Awards = $1,700,283

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Automated Dental Fracture Detection using High Resolution CBCT and Advanced Image Analysis

Award Number: R44DE027574

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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