Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Award Number: R44DC012967
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2016

Group Awards By:

View Award Description

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening - DESCRIPTION (provided by applicant): Universal newborn hearing screening is mandated in the US and is performed in the postpartum hospital setting. Current physiology-based hearing screening tests are unable to detect late-onset hearing loss caused by cytomegalovirus (CMV) infection. Therefore, a complementary screening approach has been suggested to prevent disabilities associated with CMV-related hearing loss by early detection and intervention. A nucleic acid test has been described to screen newborns for congenital CMV infection using saliva specimens where it is more sensitive than the dried blood spots traditionally used by the newborn screening laboratories. Newborn screening programs do not have the infrastructure necessary to use newborn saliva samples and molecular assays. Advanced Liquid Logic's digital microfluidic technology is a recognized innovative, low-cost, and automated liquid handling system that can address this challenge. The objective of this Fast-Track application is to develop an integrated lab-on-a-chip to perform screening of congenital CMV infection in newborns using saliva samples. Specific aims in Phase I are to develop protocols for CMV purification from saliva samples and for viral DNA amplification on-cartridge, and to integrate a "sample-to-answer" CMV screening assay on the digital microfluidic platform. Success in Phase I will result in a Phase II continuation where the specific aims will be (i) to develop a point-of-care newborn screening platform, (ii) to optimize the "sample-to-answer" CMV protocol in this platform and assess its analytical performance, and (iii) to perform a method comparison with the "gold standard" rapid saliva culture using neonatal saliva samples in collaboration with the University of Alabama at Birmingham.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	BAEBIES, INC.	615 DAVIS DR STE 800	DURHAM	NC	27709	DURHAM	USA	Research Related to Deafness and Communication Disorders	000	3	2/2/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $498,598 )
2014	2014	BAEBIES INC	PO BOX 14403	DURHAM	NC	27709	DURHAM	USA	Research Related to Deafness and Communication Disorders	000	3	8/14/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$498,598
														Subtotal = $498,598

Issue Date FY: 2013 ( Subtotal = $879,941 )
2013	2013	ADVANCED LIQUID LOGIC INC	615 DAVIS DRIVE	MORRISVILLE	NC	27560	WAKE	USA	Research Related to Deafness and Communication Disorders	000	1	11/24/2012	NEW	$198,668
2013	2013	ADVANCED LIQUID LOGIC INC	615 DAVIS DRIVE	MORRISVILLE	NC	27560	WAKE	USA	Research Related to Deafness and Communication Disorders	002	2	5/21/2013	EXTENSION WITH OR WITHOUT FUNDS	$681,273
2013	2013	ADVANCED LIQUID LOGIC INC	615 DAVIS DRIVE	MORRISVILLE	NC	27560	WAKE	USA	Research Related to Deafness and Communication Disorders	001	1	5/17/2013	NEW	$0
														Subtotal = $879,941

Grand Total All Awards = $1,378,539

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Award Number: R44DC012967

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2016

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer