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DENSE ARRAY EEG FOR NEONATAL SLEEP MONITORING

Award Number: R44DA020431
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2009

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DENSE ARRAY EEG FOR NEONATAL SLEEP MONITORING - DESCRIPTION (PROVIDED BY APPLICANT): Electroencephalography (EEG) is a safe, noninvasive technique for monitoring neonatal brain function. Acute and long-term EEG monitoring of infants has clinical utility for evaluating the effects of hypoxic ischemic insults and detecting the presence of epileptic activity. Medical intervention may be effective for several neonatal brain pathologies if these are detected early. In Sudden Infant Death Syndrome (SIDS), for example, disorders in the neurophysiology of sleep regulation may be potentially life-threatening for many infants, and may be amenable to treatment, but we have a limited understanding of both the normal neonatal sleep neurophysiology and its disregulation. The information available in neonatal EEG can be greatly enhanced by using an adequate number of electrodes to accurately map the spatial distribution of the EEG without spatial aliasing. The Geodesic EEG Neonatal Brain Monitor will be designed from experimental studies and theoretical simulations of the required sampling density for scalp potentials on the infant head. Dense Array EEG methods will be developed that incorporate the unique features of infant skull anatomy to estimate the potentials in the brain of the infant. The Geodesic EEG Neonatal Brain Monitor will be adapted for a variety of clinical uses, initially focusing on monitoring brain function in sleep in the Neonatal Intensive Care Unit (NICU). A low-cost product line would result from the Phase II work, ranging from simple 4- channel EEG with vital signs monitors to a 256-channel dense array system. These products will bring major advances to monitoring both normal and pathological brain states of the neonate, providing information on the maturation of arousal control and sleep in preterm and full term infants that may be important in understanding a variety of clinical disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2006	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Drug Use and Addiction Research Programs	001	3	1/27/2009	NON-COMPETING CONTINUATION	$0
2009	2006	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Drug Use and Addiction Research Programs	000	3	1/26/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2006 ( Subtotal = $363,520 )
2006	2006	ELECTRICAL GEODESICS, INC	1600 MILLRACE DRIVE, STE 307	EUGENE	OR	97403	LANE	USA	Drug Use and Addiction Research Programs	000	3	9/14/2006	NON-COMPETING CONTINUATION	$363,520
														Subtotal = $363,520

Issue Date FY: 2005 ( Subtotal = $600,039 )
2005	2005	ELECTRICAL GEODESICS, INC	1900 MILLRACE DRIVE	EUGENE	OR	97403	LANE	USA	Drug Use and Addiction Research Programs	000	2	9/1/2005	OTHER REVISION	$600,039
														Subtotal = $600,039

Grand Total All Awards = $963,559

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DENSE ARRAY EEG FOR NEONATAL SLEEP MONITORING

Award Number: R44DA020431

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2009

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